Cbz-L-天门冬氨酸 4-叔丁酯合成路线 （共 37 条）
反应条件
1: H2 / Pd-C View Scheme
参考文献
Voelter,W. et al.
Chemische Berichte, 1972 , vol. 105, p. 3650 - 3657
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 2 - 3 h;
参考文献
LG LIFE SCIENCES LTD.
Patent: WO2008/16239 A1, 2008 ;
Location in patent: Page/Page column 75-76 ;
WO 2008/016239 A1
参考文献
LG Chem Investment Ltd.
Patent: US6747050 B1, 2004 ;
Location in patent: Page/Page column 44-45 ;
反应条件
in methanol; toluene
T=20°C; 0.25 h;
参考文献
Heredia-Moya, Jorge; Kirk, Kenneth L.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5908 - 5913
反应条件
1: N-methyl morpholine / ethyl acetate / 0.25 h
2: ethyl acetate; diethyl ether / 4 h / 0 °C
3: silver benzoate, Et3N / methanol
View Scheme
参考文献
Misiti; Santaniello; Zappia
Synthetic Communications, 1992 , vol. 22, # 6 p. 883 - 891
反应条件
1: diethyl ether
2: H2, AcOH / Pd / methanol
View Scheme
参考文献
Wuensch,E.; Zwick,A.
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1963 , vol. 333, p. 108 - 113
反应条件
(i) CH2Cl2, (ii) H2, Pd-C, EtOH; Multistep reaction;
参考文献
Bernardi,L. et al.
Gazzetta Chimica Italiana, 1964 , vol. 94, p. 853 - 865
