2-[(4-羧甲基苯氧基)甲基]苯甲酸合成路线 （共 6 条）
反应条件
1: With methanol; sodium hydroxide; water T=65°C; 2 h; 2: With water; acetic acid in methanol T=60°C; 2 h;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2058294 A1, 2009 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: With sodium methylate in methanol; N,N-dimethyl-formamide T=100 - 130°C; P=600.06 - 760.051 Torr; 2: With water in methanol; N,N-dimethyl-formamide T=100°C; 3: With hydrogenchloride in methanol; water; N,N-dimethyl-formamide T=10°C; pH=1;
参考文献
Bader, Thomas; Bichsel, Hans-Ulrich; Gilomen, Bruno; Meyer-Wilmes, Imelda; Sundermeier, Mark
Patent: US2007/232814 A1, 2007 ;
Location in patent: Page/Page column 23 ;
反应条件
1: K2CO3, KI / butan-2-one / 24 h / Heating 2: KOH / aq. ethanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 246 - 252
反应条件
1: K2CO3, KI / butan-2-one / 24 h / Heating 2: KOH / aq. ethanol / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 246 - 252
反应条件
1: With trifluoroacetic anhydride in chlorobenzene T=20°C; 4 h; 2: With boron trifluoride diethyl etherate in chlorobenzene T=-10 - 0°C; 0.666667 h;
参考文献
EP2072507 A1, ;
Page/Page column 10-11 ;
反应条件
1.1: acetic acid / 2.5 h / 70 - 75 °C 2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere 2.2: 0 °C / Reflux 2.3: 0.25 h / 25 - 30 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SATYANARAYANA, Komati
Patent: WO2011/128911 A2, 2011 ;
