1-氰基-1-(对氯苯基)-2-丁酮合成路线 （共 4 条）
反应条件
1: (p-chlorophenyl)acetonitrile With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.166667 h; 2: propionyl chloride in tetrahydrofuran T=-78°C; Further stages.;
参考文献
Tarnchompoo, Bongkoch; Sirichaiwat, Chawanee; Phupong, Worrapong; Intaraudom, Chakapong; Sirawaraporn, Worachart; Kamchonwongpaisan, Sumalee; Vanichtanankul, Jarunee; Thebtaranonth, Yodhathai; Yuthavong, Yongyuth
Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1244 - 1252
反应条件
1: (p-chlorophenyl)acetonitrile With lithium hexamethyldisilazane in tetrahydrofuran; diethyl ether T=-78°C; 0.166667 h; 2: propionic acid ethyl ester in tetrahydrofuran; diethyl ether T=20°C; 72 h; Further stages.;
参考文献
El-Hamamsy, Mervat H.R.I.; Smith, Anthony W.; Thompson, Andrew S.; Threadgill, Michael D.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 13 p. 4552 - 4576
反应条件
diethyl ether anschliessenden Erwaermen mit Guanidin in Aethanol;
参考文献
Russell; Hitchings
Journal of the American Chemical Society, 1951 , vol. 73, p. 3763,3766
反应条件
1: dioxane / 20 °C 2: 0.70 g / dimethylsulfoxide / 0.08 h / 80 °C View Scheme
参考文献
Chase; Walker
Journal of the Chemical Society, 1953 , p. 3518,3523
