2-氯-1-(2-吡啶基)乙酮合成路线 （共 8 条）
反应条件
hydrogen fluoride in acetonitrile
2 h;
参考文献
Tanis, Steven P.; Evans, Bruce R.; Nieman, James A.; Parker, Timothy T.; Taylor, Wendy D.; Heasley, Steven E.; Herrinton, Paul M.; Perrault, William R.; Hohler, Richard A.; Dolak, Lester A.; Hester, Matthew R.; Seest, Eric P.
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2154 - 2182
反应条件
1: 2-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran
T=20°C;
2: chloroacetic acid N-methyl-N-methoxy-amide in tetrahydrofuran
参考文献
Tanis, Steven P.; Evans, Bruce R.; Nieman, James A.; Parker, Timothy T.; Taylor, Wendy D.; Heasley, Steven E.; Herrinton, Paul M.; Perrault, William R.; Hohler, Richard A.; Dolak, Lester A.; Hester, Matthew R.; Seest, Eric P.
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2154 - 2182
反应条件
[2,2']bipyridinyl; copper(l) chloride in 1,2-dichloro-ethane
3 h; Heating;
参考文献
Ram, Ram N.; Manoj
Journal of Organic Chemistry, 2008 , vol. 73, # 14 p. 5633 - 5635
反应条件
1: 2-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran
T=20 - 25°C; 12 h;
2: 2-chloro-1-morpholin-4-yl-ethanone in tetrahydrofuran
T=-25 - -20°C;
参考文献
Tanis, Steven P.; Evans, Bruce R.; Nieman, James A.; Parker, Timothy T.; Taylor, Wendy D.; Heasley, Steven E.; Herrinton, Paul M.; Perrault, William R.; Hohler, Richard A.; Dolak, Lester A.; Hester, Matthew R.; Seest, Eric P.
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2154 - 2182
反应条件
1: 2-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran
T=20°C;
2: chloroacetic acid N-methyl-N-methoxy-amide in tetrahydrofuran
T=-25 - 0°C;
3: With water in tetrahydrofuran
参考文献
Bradley, Paul A.; Lecouturier, Yann C.; Noeureuil, Pierre; Patel, Bhairavi; Wheeler, Simon; Carroll, Robert J.; Moore, Robert; Snow, Jonathan
Organic Process Research and Development, 2010 , vol. 14, # 6 p. 1326 - 1336
反应条件
1: alpha-chloropyridine With magnesium in tetrahydrofuran
T=40°C;
2: chloroacetic acid N-methyl-N-methoxy-amide in tetrahydrofuran
参考文献
Tanis, Steven P.; Evans, Bruce R.; Nieman, James A.; Parker, Timothy T.; Taylor, Wendy D.; Heasley, Steven E.; Herrinton, Paul M.; Perrault, William R.; Hohler, Richard A.; Dolak, Lester A.; Hester, Matthew R.; Seest, Eric P.
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2154 - 2182
反应条件
1: NCS / tetrahydrofuran / 2 h / Heating
2: 85 percent / aqueous HF / acetonitrile / 2 h
View Scheme
参考文献
Tanis, Steven P.; Evans, Bruce R.; Nieman, James A.; Parker, Timothy T.; Taylor, Wendy D.; Heasley, Steven E.; Herrinton, Paul M.; Perrault, William R.; Hohler, Richard A.; Dolak, Lester A.; Hester, Matthew R.; Seest, Eric P.
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2154 - 2182
反应条件
1: i-Pr2NEt / CH2Cl2 / cooling
2: NCS / tetrahydrofuran / 2 h / Heating
3: 85 percent / aqueous HF / acetonitrile / 2 h
View Scheme
参考文献
Tanis, Steven P.; Evans, Bruce R.; Nieman, James A.; Parker, Timothy T.; Taylor, Wendy D.; Heasley, Steven E.; Herrinton, Paul M.; Perrault, William R.; Hohler, Richard A.; Dolak, Lester A.; Hester, Matthew R.; Seest, Eric P.
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2154 - 2182
