2-氯-1-(吡啶-3-基)乙酮合成路线 （共 6 条）
反应条件
formic acid; triethylamine; RuCl[(1R,2R)-p-TsNCH(Ph)-CH(Ph)NH2](η6-p-cymene) T=20°C; Noyori asymmetric transfer hydrogenation; P=30 Torr; 0.75 h;
参考文献
Tanis, Steven P.; Evans, Bruce R.; Nieman, James A.; Parker, Timothy T.; Taylor, Wendy D.; Heasley, Steven E.; Herrinton, Paul M.; Perrault, William R.; Hohler, Richard A.; Dolak, Lester A.; Hester, Matthew R.; Seest, Eric P.
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2154 - 2182
反应条件
formic acid; triethylamine; chloro[(1R,2R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine] (pentamethylcyclopentadienyl) rhodium in ethyl acetate T=25°C; 2 h; Title compound not separated from byproducts.;
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: WO2004/85414 A1, 2004 ;
Location in patent: Page 28 ;
反应条件
triethylamine in tetrahydrofuran
T=17°C; 1 h;
参考文献
Duquette, Jason; Zhang, Mingbao; Zhu, Lei; Reeves, Raymond S.
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 285 - 288
反应条件
chloroform; chlorine
参考文献
Dornow et al.
Chemische Berichte, 1951 , vol. 84, p. 147,149
反应条件
hydrogenchloride; water
参考文献
Dornow
Chemische Berichte, 1940 , vol. 73, p. 185,187
反应条件
hydrogenchloride in ethanol
参考文献
Westphal,G. et al.
Journal fuer Praktische Chemie (Leipzig), 1976 , vol. 318, p. 875 - 877
