2’-O-甲基-5-甲基尿苷合成路线 （共 28 条）
反应条件
1: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 2: 30percent NaOMe / methanol / Ambient temperature; pH 11 3: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
反应条件
1: 98 percent / 30percent NaOMe / methanol / 3 h / Ambient temperature 2: 98 percent / NaH / tetrahydrofuran / 40 - 70 °C 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: 30percent NaOMe / methanol / Ambient temperature; pH 11 5: 84 percent / H2, NaOAc / 5percent Pd/C / methanol / 45 °C / 2250.2 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 78, # 2 p. 486 - 504
反应条件
ammonia in methanol; water
参考文献
Journal of Organic Chemistry, , vol. 68, # 17 p. 6502 - 6510
反应条件
1: pyridine; DMAP / 20 °C 2: dimethylformamide / 2.5 h / 100 °C 3: pyridine / 20 °C 4: 93 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 5: NH3 / methanol; H2O View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 17 p. 6502 - 6510
反应条件
1: dimethylformamide / 2.5 h / 100 °C 2: pyridine / 20 °C 3: 93 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C 4: NH3 / methanol; H2O View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 17 p. 6502 - 6510
反应条件
1: PhO2CO / dimethylformamide 2: 93 percent / NaHCO3, (MeO)3CH / methanol / 42 h / 150 °C / 10343 Torr View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 16, # 7-9 p. 1641 - 1643
反应条件
1: 55 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.5 h / Ambient temperature 2: 80 percent / conc. aq. NH4OH / methanol / 24 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 765 - 769
反应条件
1: 55 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.5 h / Ambient temperature 2: 80 percent / conc. aq. NH4OH / methanol / 24 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 765 - 769
反应条件
1: ammonium sulfate / 16 h / Heating 2: 55 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.5 h / Ambient temperature 3: 80 percent / conc. aq. NH4OH / methanol / 24 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 765 - 769
反应条件
1: 71 percent / CH2N2, BF3*OEt2 / CH2Cl2 / 0.5 h / 4 °C 2: 55 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.5 h / Ambient temperature 3: 80 percent / conc. aq. NH4OH / methanol / 24 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 4 p. 765 - 769
