2-(2'-羟基-4'-二乙基氨基苯基)苯并噻唑合成路线 （共 7 条）
反应条件
sodium hydroxide; lauryl mercaptan in 1-methyl-pyrrolidin-2-one
T=130°C;
参考文献
Santra, Mithun; Moon, Hyunsoo; Park, Min-Ho; Lee, Tae-Woo; Kim, Young Kook; Ahn, Kyo Han
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9886 - 9893
反应条件
phosphorus trichoride in toluene
4 h; Heating;
参考文献
Anthony, Kevin; Brown, Robert G.; Hepworth, John D.; Hodgson, Kevin W.; May, Bernadette; West, Michael A.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , p. 2111 - 2118
反应条件
1: With phosphorus trichoride in ethanol
T=40 - 60°C; 4 h;
2: With sodium hydrogencarbonate in ethanol; water
T=20°C; pH=8;
参考文献
Padalkar, Vikas S.; Tathe, Abhinav; Gupta, Vinod D.; Patil, Vikas S.; Phatangare, Kiran; Sekar
Journal of Fluorescence, 2012 , vol. 22, # 1 p. 311 - 322
反应条件
1.1: trichlorophosphate / 5 - 10 °C
1.2: 4 h / 5 - 75 °C
1.3: Cooling with ice
2.1: phosphorus trichoride / ethanol / 4 h / 40 - 60 °C
2.2: 20 °C / pH 8
View Scheme
参考文献
Padalkar, Vikas S.; Tathe, Abhinav; Gupta, Vinod D.; Patil, Vikas S.; Phatangare, Kiran; Sekar
Journal of Fluorescence, 2012 , vol. 22, # 1 p. 311 - 322
反应条件
1: polyphosphoric acid / 180 °C
2: sodium hydride / N,N-dimethyl-formamide / 1.17 h / 25 °C / Inert atmosphere
3: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 25 °C / Reflux
4: sodium hydroxide; lauryl mercaptan / 1-methyl-pyrrolidin-2-one / 130 °C
View Scheme
参考文献
Santra, Mithun; Moon, Hyunsoo; Park, Min-Ho; Lee, Tae-Woo; Kim, Young Kook; Ahn, Kyo Han
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9886 - 9893
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 1.17 h / 25 °C / Inert atmosphere
2: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 25 °C / Reflux
3: sodium hydroxide; lauryl mercaptan / 1-methyl-pyrrolidin-2-one / 130 °C
View Scheme
参考文献
Santra, Mithun; Moon, Hyunsoo; Park, Min-Ho; Lee, Tae-Woo; Kim, Young Kook; Ahn, Kyo Han
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9886 - 9893
反应条件
1: polyphosphoric acid / 180 °C
2: sodium hydride / N,N-dimethyl-formamide / 1.17 h / 25 °C / Inert atmosphere
3: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 25 °C / Reflux
4: sodium hydroxide; lauryl mercaptan / 1-methyl-pyrrolidin-2-one / 130 °C
View Scheme
参考文献
Santra, Mithun; Moon, Hyunsoo; Park, Min-Ho; Lee, Tae-Woo; Kim, Young Kook; Ahn, Kyo Han
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9886 - 9893
