反应条件
1: H2N(CH2)2NH2 / dimethylsulfoxide / 2 h / 8 - 10 °C
2: 1.) EtMgBr, 2.) CuCl / 1.) THF, from 50 deg C to 60 deg C, 1 h, 2.) THF, 60 deg C, 1 h
3: HCl, MeOH
4: pyridine
5: NaI, Me3SiCl / acetonitrile
6: 1.) LiN(i-Pr)2, 2.) HMPA
7: H2, quinoline / Pd/BaSO4 / ethyl acetate
8: lithium t-butyl thiolate / dimethylformamide
View Scheme
参考文献
Tyman, John H.P.; Visani
Chemistry and Physics of Lipids, 1997 , vol. 85, # 2 p. 157 - 174
