反应条件
1.1: 95 percent / tetrahydrofuran / 0.67 h / -50 °C
2.1: B2H6 / tetrahydrofuran / 20 h / 0 °C
2.2: 82 percent / aq. NaOH; H2O2 / 0.5 h / 0 °C
3.1: 95 percent / imidazole / dimethylformamide / 1.2 h / -30 - -20 °C
4.1: 97 percent / triphenylphosphine; hydrazoic acid; diethyl azodicarboxylate / tetrahydrofuran; benzene / 2 h / 20 °C
5.1: 70 percent / propane-1,3-dithiol; Et3N / methanol / 12 h / 20 °C
6.1: 82 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Jiang, Yongying; Han, Jiye; Yu, Chengzhi; Vass, Simon O.; Searle, Peter F.; Browne, Patrick; Knox, Richard J.; Hu, Longqin
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4333 - 4343
