1: 2-methoxybromobenzene With magnesium in tetrahydrofuran
Heating;
2: 4-nitrobenzaldehdye in tetrahydrofuran
T=0 - 20°C; 3 h;
3: With dipyridinium dichromate; 4 A molecular sieve in dichloromethane
T=20°C; 2 h; Further stages.;
1: dichloromethane / 20 - 25 °C / |Inert atmosphere
2: diisobutylaluminium hydride / dichloromethane; toluene / 1.5 h / -78 °C / |Inert atmosphere
3: phosphorus tribromide / diethyl ether / 0 °C / |Inert atmosphere; |Darkness
4: tetrahydrofuran; water / 0.17 h / 20 - 25 °C / |Inert atmosphere
View Scheme
参考文献
West, Thomas H.; Daniels, David S. B.; Slawin, Alexandra M. Z.; Smith, Andrew D.
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4476 - 4479
