7-乙基-2-甲基-4-氧代-4,7-二氢噻吩并(2,3-b)吡啶-5-羧酸合成路线 （共 4 条）
反应条件
hydrogenchloride in ethanol; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US3951989 A1, 1976 ;
反应条件
sodium hydroxide
1 h; Heating;
参考文献
Gilis; Haemers; Bollaert
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 265 - 269
反应条件
1: 1.) KOH / 1.) acetone, reflux, 3 h; 2.) DMF, reflux, 10 h
2: 70 percent / polyphosphoric acid / 0.33 h / 120 °C
3: 0.1N NaOH / ethanol / Ambient temperature
View Scheme
参考文献
Bompart; Giral; Malicorne; Puygrenier
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 2 p. 139 - 145
反应条件
1: (i) NaH, DMF, (ii) /BRN= 1209224/
2: aq. NaOH / 1 h / Heating
View Scheme
参考文献
Gilis; Haemers; Bollaert
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 265 - 269
