4-羟基噻吩[2,3-b]吡啶-5-羧酸合成路线 （共 8 条）
反应条件
sodium hydroxide
0.5 h; Heating;
参考文献
Khan,M.A.; Guarconi,A.E.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 807 - 812
反应条件
1: diphenyl ether / 1.5 h / Heating
2: aq. NaOH / 0.5 h / Heating
View Scheme
参考文献
Khan,M.A.; Guarconi,A.E.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 807 - 812
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2005/234091 A1, 2005 ;
Location in patent: Page/Page column 44 ;
US 20050234091 A1
反应条件
(i) K2CO3, DMF, (ii) /BRN= 969135/; Multistep reaction;
参考文献
Gilis; Haemers; Bollaert
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 265 - 269
反应条件
(i) K2CO3, DMF, (ii) /BRN= 385801/; Multistep reaction;
参考文献
Gilis; Haemers; Bollaert
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 265 - 269
反应条件
(i) K2CO3, DMF, (ii) /BRN= 505936/; Multistep reaction;
参考文献
Gilis; Haemers; Bollaert
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 265 - 269
反应条件
potassium hydroxide in ethanol
50 h; Heating;
参考文献
Khan,M.A.; Guarconi,A.E.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 807 - 812
反应条件
1: 1 h / Heating
2: POCl3 / 2 h / Heating
View Scheme
参考文献
Khan,M.A.; Guarconi,A.E.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 807 - 812
