7-乙基-4-氧代-4,7-二氢噻吩并[2,3-b]吡啶-5-羧酸合成路线 （共 5 条）
反应条件
1: 1.) KOH / 1.) acetone, reflux, 3 h; 2.) DMF, reflux, 10 h
2: 80 percent / polyphosphoric acid / 0.33 h / 120 °C
3: 0.1N NaOH / ethanol / Ambient temperature
View Scheme
参考文献
Bompart; Giral; Malicorne; Puygrenier
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 2 p. 139 - 145
反应条件
sodium hydroxide
1 h; Heating;
参考文献
Gilis; Haemers; Bollaert
European Journal of Medicinal Chemistry, 1978 , vol. 13, # 3 p. 265 - 269
反应条件
1: 80 percent / polyphosphoric acid / 0.33 h / 120 °C
2: 0.1N NaOH / ethanol / Ambient temperature
View Scheme
参考文献
Bompart; Giral; Malicorne; Puygrenier
European Journal of Medicinal Chemistry, 1987 , vol. 22, # 2 p. 139 - 145
反应条件
1: aq. NaOH / 0.5 h / Heating
2: aq. KOH / ethanol / 50 h / Heating
View Scheme
参考文献
Khan,M.A.; Guarconi,A.E.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 807 - 812
反应条件
potassium hydroxide in ethanol
50 h; Heating;
参考文献
Khan,M.A.; Guarconi,A.E.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 807 - 812
