5-乙烯基-2'-脱氧尿苷合成路线 （共 22 条）
反应条件
hydrogen; palladium on activated charcoal in methanol P=1241.2 Torr; 10 h;
参考文献
Hassan, Mohamed Ezeldin
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 9 p. 1944 - 1948
反应条件
tributyl-amine; palladium diacetate in N,N-dimethyl-formamide
T=80°C; Heck reaction; 0.333333 h; Microwave irradiation;
参考文献
Ogino, Masayuki; Taya, Yuuta; Fujimoto, Kenzo
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 15 p. 3163 - 3167
反应条件
water; triethylamine in N,N-dimethyl-formamide
T=105°C; 24 h;
参考文献
Jones, A. Stanley; McClean, Michael J.; Slater, Martin J.; Walker, Richard T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 457 - 464
反应条件
1: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature
2: 2 M NaOH / 2 h / Ambient temperature
3: H2 / Lindlar catalyst (poisoned)
View Scheme
参考文献
Lambert, Robert W.; Martin, Joseph A.; Thomas, Gareth J.; Duncan, Ian B.; Hall, Michael J.; Heimer, Edgar P.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 367 - 374
反应条件
1: pyridine / 24 h
2: 0.16 g / 80percent aq. HOAc / 4.5 h
3: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature
4: 2 M NaOH / 2 h / Ambient temperature
5: H2 / Lindlar catalyst (poisoned)
View Scheme
参考文献
Lambert, Robert W.; Martin, Joseph A.; Thomas, Gareth J.; Duncan, Ian B.; Hall, Michael J.; Heimer, Edgar P.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 367 - 374
反应条件
1: 0.16 g / 80percent aq. HOAc / 4.5 h
2: dicyclohexylcarbodiimide / pyridine / 72 h / Ambient temperature
3: 2 M NaOH / 2 h / Ambient temperature
4: H2 / Lindlar catalyst (poisoned)
View Scheme
参考文献
Lambert, Robert W.; Martin, Joseph A.; Thomas, Gareth J.; Duncan, Ian B.; Hall, Michael J.; Heimer, Edgar P.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 367 - 374
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=90°C; 72 h;
参考文献
Jones, A. Stanley; McClean, Michael J.; Slater, Martin J.; Walker, Richard T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 457 - 464
反应条件
1: 89 percent / pyridine, EtN-iPr2 / 3 h / Ambient temperature
2: Pd(Ph3P)4 / hexamethylphosphoric acid triamide / 60 °C
3: MeONa / methanol
View Scheme
参考文献
Herdewijn; Kerremans; Wigerinck; Vandendriessche; Van Aerschot
Tetrahedron Letters, 1991 , vol. 32, # 34 p. 4397 - 4400
反应条件
1: Pd(Ph3P)4 / hexamethylphosphoric acid triamide / 60 °C
2: MeONa / methanol
View Scheme
参考文献
Herdewijn; Kerremans; Wigerinck; Vandendriessche; Van Aerschot
Tetrahedron Letters, 1991 , vol. 32, # 34 p. 4397 - 4400
反应条件
thymidine phosphorylase in aq. phosphate buffer
T=37°C; pH=6.8; 0.3 h; Enzymatic reaction;
参考文献
Hatano, Akihiko; Kurosu, Masayuki; Yonaha, Susumu; Okada, Munehiro; Uehara, Sanae
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 40 p. 6900 - 6905
