Boc-4-氨基-L-苯丙氨酸合成路线 （共 11 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=1810.07 Torr; 2 h;
参考文献
EP1144365 B1, ;
Page 71 ;
反应条件
palladium 10 on activated carbon; hydrogen in methanol Inert atmosphere;
参考文献
Molecular Pharmaceutics, , vol. 8, # 5 p. 1857 - 1866
反应条件
1: 53 percent / HNO3; H2SO4 2: 92 percent / dioxane; H2O / 24 h / 0 - 20 °C 3: H2 / Pd/C / methanol / 1 h / 3102.89 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 10 p. 3467 - 3475
反应条件
1: 92 percent / dioxane; H2O / 24 h / 0 - 20 °C 2: H2 / Pd/C / methanol / 1 h / 3102.89 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 10 p. 3467 - 3475
反应条件
1: 67.2 percent / Et3N, / dioxane; H2O / Ambient temperature 2: 84.9 percent / H2 / Pd / methanol View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 6 p. 1079 - 1090
反应条件
1: 78 percent 2: 84 percent / H2 / Raney nickel / 24 h / 2585.7 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 3 p. 638 - 643
反应条件
1: tetrahydrofuran / 1 h / 20 °C 2: H2O / 60 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 25 p. 4467 - 4470
反应条件
in 1,4-dioxane; water
参考文献
Landis; Lui; Shook; Yamamura; Burks; Hruby
Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 638 - 643
反应条件
sodium hydroxide in 1,4-dioxane pH 9;
参考文献
Theobald, Paula; Porter, John; Rivier, Catherine; Corrigan, Anne; Hook, William; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2395 - 2402
反应条件
imidazole-1-sulfonyl azide hydrochloride; triethylamine; zinc(II) chloride in methanol; acetonitrile T=20°C; 12 h; DarknessInert atmosphere;
参考文献
Strom, T. Amanda; Barron, Andrew R.
Chemical Communications, 2010 , vol. 46, # 26 p. 4764 - 4766
