N,N-二甲基-3-苯基-3-羟基丙胺合成路线 (共 12 条)
反应条件
hydrogenchloride in di-isopropyl ether
T=0°C; 1 h;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2009/141833 A2, 2009 ;
Location in patent: Page/Page column 11 ;
反应条件
1: N,N-dimethyl-3-phenyl-3-hydroxy-propanamine With methanesulfonyl chloride; triethylamine in acetonitrile
T=20°C; 3 h;
2: 4-(trifluoromethyl)phenol With potassium carbonate in acetonitrile
16 h; Heating;
参考文献
O'Brien, Peter; Phillips, David W.; Towers, Timothy D.
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7333 - 7335