4-(4-甲氧基苯基)-2,4-二氧丁酸合成路线 （共 8 条）
反应条件
sodium hydroxide; sulfuric acid in water
T=20°C;
参考文献
Braga, Remi; Hecquet, Laurence; Blonski, Casimir
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2965 - 2972
反应条件
1: 25 percent / sodium hydride / toluene / 80 °C
2: 61 percent / sodium hydroxide; H2SO4 / H2O / 20 °C
View Scheme
参考文献
Braga, Remi; Hecquet, Laurence; Blonski, Casimir
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 2965 - 2972
参考文献
Robinson; Schwarzenbach
Journal of the Chemical Society, 1930 , p. 822,826
反应条件
1: 62 percent / aq. formic acid; aq. HCl / 5 °C
2: 97 percent / NaBH4 / methanol / 0.08 h / Ambient temperature
3: 79 percent / Pb(OAc)4 / acetic acid; acetic anhydride / 2 h / 50 °C
4: 66 percent / phenol, 48percent HBr / 16 h / Heating
View Scheme
参考文献
Sweeny, J.G.; Iacobucci, G.A.
Tetrahedron, 1981 , vol. 37, p. 1481 - 1484
参考文献
Andreichikov, Yu. S.; Gein, L. F.; Gein, V. L.; Ionov, Yu. V.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, p. 988
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 5 p. 1116 - 1117
反应条件
1: 1N NaOH / H2O; acetic acid / Ambient temperature; overnight
2: ethanol / 12 h / Heating
3: 62 percent / phosphorus pentasulfide / pyridine / 3 h / Heating
4: 1.) sodium methoxide; / 1.) methanol; 2.) room temp., overnight
View Scheme
参考文献
Eid, M. M.; Badawy, M. A.; Ghazala, M. A. H.; Ibrahim, Yehia A.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1709 - 1711
反应条件
1: 1N NaOH / H2O; acetic acid / Ambient temperature; overnight
2: ethanol / 12 h / Heating
3: 62 percent / phosphorus pentasulfide / pyridine / 3 h / Heating
View Scheme
参考文献
Eid, M. M.; Badawy, M. A.; Ghazala, M. A. H.; Ibrahim, Yehia A.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1709 - 1711
反应条件
acetic anhydride
T=60 - 70°C; Cyclization;
参考文献
Igidov; Koz'minykh; Sof'ina; Shironina
Chemistry of Heterocyclic Compounds, 1999 , vol. 35, # 11 p. 1276 - 1285
