4,4'-二溴-3,3'-联噻吩合成路线 （共 5 条）
反应条件
1: With n-butyllithium in diethyl ether T=-78°C; 2 h; 2: With methanol in diethyl ether T=-78 - 20°C; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 78, # 6 p. 2726 - 2730
反应条件
1: With tert.-butyl lithium in diethyl ether
T=-78°C;
2: in diethyl ether
3: With 2,3,5,6-tetramethyl-p-benzoquinone in diethyl ether
参考文献
Miyake, Yoshihiro; Wu, Mo; Rahman, M. Jalilur; Iyoda, Masahiko
Chemical Communications, 2005 , # 3 p. 411 - 413
反应条件
copper(II) nitrate in tetrahydrofuran
T=23°C; Decomposition; coupling;
参考文献
Harada, Genta; Yoshida, Masato; Iyoda, Masahiko
Chemistry Letters, 2000 , # 2 p. 160 - 161
反应条件
1: With n-butyllithium in diethyl ether
T=-78°C;
2: With (PhSO2)2S in diethyl ether
T=-78 - 20°C; Inert atmosphere; Temperature;
参考文献
Han, Hui; Zhao, Wenling; Song, Jinsheng; Li, Chunli; Wang, Hua
Journal of Organic Chemistry, 2013 , vol. 78, # 6 p. 2726 - 2730
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Metallation; 2 h;
2: With zinc(II) chloride in tetrahydrofuran; hexane
T=-50°C; Substitution; 2 h;
3: With copper dichloride in tetrahydrofuran; hexane
T=-78°C; Cyclization; 2 h;
参考文献
Kabir, S. M. Humayun; Miura, Mami; Sasaki, Shigeru; Harada, Genta; Kuwatani, Yoshiyuki; Yoshida, Masato; Iyoda, Masahiko
Heterocycles, 2000 , vol. 52, # 2 p. 761 - 774
