5-(4-氟苯基)环己烷-1,3-二酮合成路线 （共 5 条）
反应条件
1: With sodium in methanol T=80°C; 4 h; 2: With sodium hydroxide in methanol; water T=80°C; 0.666667 h; 3: With hydrogenchloride in methanol; water Reflux;
参考文献
UNIVERSITY OF ROCHESTER; SOUTHERN RESEARCH INSTITUTE; GOLDFARB, David, S.; MADDRY, Joseph, A.; RASMUSSEN, Lynn; WHITE, Ellie, Lucile; WENNERBERG, Krister
Patent: WO2011/62964 A1, 2011 ;
Location in patent: Page/Page column 21 ;
反应条件
1: aq. NaOH 2: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 20, p. 709 - 714
反应条件
sodium carbonate; trichlorophosphate in toluene
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: POCl3, Na2CO3 / toluene
2: Na / toluene
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: POCl3, Na2CO3 / toluene
2: Na / toluene
3: Br2 / benzene
4: aq. NaOH / methanol
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
