2,5-二氨基-4,6-二氯嘧啶合成路线 （共 11 条）
反应条件
1: With anhydrous tetramethylammonium chloride; trichlorophosphate in 1,2,3-trichloro propane T=115°C; 24 h; 2: With sodium hydroxide in 1,2,3-trichloro propane; water T=50 - 60°C; pH=6.5 - 7.0; 0.5 h;
参考文献
Lonza AG
Patent: EP1188750 A1, 2002 ;
Location in patent: Page 5 ;
反应条件
hydrogenchloride in ethanol; water Hydrolysis; 6 h; Heating;
参考文献
Daluge, Susan M.; Martin, Michael T.; Sickles, Barry R.; Livingston, Douglas A.
Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 1-2 p. 297 - 327
参考文献
Beecham Group p.l.c.
Patent: US5216161 A1, 1993 ;
反应条件
phosphoric acid in ethanol; water
反应条件
sodium hydroxide; trichlorophosphate in ethyl acetate; acetonitrile
反应条件
sodium hydroxide; anhydrous tetramethylammonium chloride; trichlorophosphate in tetrahydrofuran; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane
参考文献
Journal of Organic Chemistry, , vol. 19, p. 930,932
反应条件
1: T=50 - 55°C; 3 h; 2: in toluene T=50°C; under reduced pressure;
参考文献
Lonza AG
Patent: EP1188750 A1, 2002 ;
Location in patent: Page 5 ;
反应条件
formic acid in water; toluene
参考文献
Lonza AG
Patent: US6271376 B1, 2001 ;
反应条件
triethylamine in butan-1-ol
72 h; Heating;
参考文献
Legraverend; Boumchita; Bisagni
Synthesis, 1990 , # 7 p. 587 - 589
