1-(3,4-二氢-2(1H)-异喹啉基)-2,2,2-三氟乙烷酮合成路线 （共 6 条）
反应条件
chlorosulfonic acid in chloroform 60 h; Ambient temperature;
参考文献
SmithKline Corporation
Patent: US4228170 A1, 1980 ;
参考文献
Ali; Gleason; Hill; Krell; Kruse; Lavanchy; Volpe
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1235 - 1240
反应条件
trifluoroacetic anhydride in tetrahydrofuran
参考文献
Ishihara, Yuji; Terauchi, Jun; Suzuki, Nobuhiro; Takekawa, Shiro; Aso, Kazuyoshi
Patent: US2003/158177 A1, 2003 ;
反应条件
sulfuric acid in acetic acid
T=20°C; 120 h;
参考文献
Stokker
Tetrahedron Letters, 1996 , vol. 37, # 31 p. 5453 - 5456
反应条件
1: 0.5 h / -5 °C
2: 80 percent / 20 percent H2SO4 / acetic acid / 120 h / 20 °C
View Scheme
参考文献
Stokker
Tetrahedron Letters, 1996 , vol. 37, # 31 p. 5453 - 5456
反应条件
1: 66 percent / AlCl3 / CS2 / 1 h / Heating
2: 83 percent / 3N aq. HCl / butan-1-ol / 3 h / Heating
View Scheme
参考文献
Ali; Gleason; Hill; Krell; Kruse; Lavanchy; Volpe
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1235 - 1240
