5-氨基-6-氯异吲哚啉-1,3-二酮合成路线 （共 4 条）
反应条件
hydrogenchloride; tin(ll) chloride
T=60°C; 0.5 h;
参考文献
Cherkez, S.; Herzig, J.; Yellin, H.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 947 - 959
反应条件
1: 66 percent / 20percent oleum, fuming nitric acid / 0.5 h / 80 °C
2: 80 percent / SnCl2*2H2O, concd. HCl / 0.5 h / 60 °C
View Scheme
参考文献
Cherkez, S.; Herzig, J.; Yellin, H.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 947 - 959
反应条件
1: 77 percent / pyridine / 130 °C
2: 66 percent / 20percent oleum, fuming nitric acid / 0.5 h / 80 °C
3: 80 percent / SnCl2*2H2O, concd. HCl / 0.5 h / 60 °C
View Scheme
参考文献
Cherkez, S.; Herzig, J.; Yellin, H.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 947 - 959
反应条件
1: 91 percent / ammonium carbonate / 2 h / 300 °C
2: 66 percent / 20percent oleum, fuming nitric acid / 0.5 h / 80 °C
3: 80 percent / SnCl2*2H2O, concd. HCl / 0.5 h / 60 °C
View Scheme
参考文献
Cherkez, S.; Herzig, J.; Yellin, H.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 947 - 959
