1-[4-[(2,4-二氨基嘧啶-5-基)甲基]-2,6-二甲氧基苯基]乙酮合成路线 （共 8 条）
反应条件
aluminium amalgam in tetrahydrofuran; water
T=60°C; 5 h;
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
in tetrahydrofuran; ethyl acetate
参考文献
Hoffmann-La Roche Inc.
Patent: US3931181 A1, 1976 ;
反应条件
1: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C
2: 95 percent / propan-2-ol / 0.5 h / Heating
3: 86 percent / sodium methylate / ethanol / 40 h / Heating
4: 1.) sodium hydride / 1.) DMF, 45 min, 65 deg C; 2.) THF-DMF, 60 deg C, 20 min
5: 58 percent / amalgamated alumina / tetrahydrofuran; H2O / 5 h / 60 °C
View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
1: 86 percent / sodium methylate / ethanol / 40 h / Heating
2: 1.) sodium hydride / 1.) DMF, 45 min, 65 deg C; 2.) THF-DMF, 60 deg C, 20 min
3: 58 percent / amalgamated alumina / tetrahydrofuran; H2O / 5 h / 60 °C
View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
1: 95 percent / propan-2-ol / 0.5 h / Heating
2: 86 percent / sodium methylate / ethanol / 40 h / Heating
3: 1.) sodium hydride / 1.) DMF, 45 min, 65 deg C; 2.) THF-DMF, 60 deg C, 20 min
4: 58 percent / amalgamated alumina / tetrahydrofuran; H2O / 5 h / 60 °C
View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
1: 1.) sodium hydride / 1.) DMF, 45 min, 65 deg C; 2.) THF-DMF, 60 deg C, 20 min
2: 58 percent / amalgamated alumina / tetrahydrofuran; H2O / 5 h / 60 °C
View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
pyridine; hydroxylamine hydrochloride in ethanol
4 h; Heating;
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
sodium tetrahydroborate in methanol; sodium hydroxide
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
