4-[(2,4-二氨基嘧啶-5-基)甲基]-2,6-二甲氧基-alpha,alpha-二甲基苯甲醇合成路线 （共 7 条）
反应条件
sodium methylate in ethanol
40 h; Heating;
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
in methanolic potassium hydroxide
参考文献
Hoffmann-La Roche Inc.
Patent: US3931181 A1, 1976 ;
参考文献
Hoffmann-La Roche Inc.
Patent: US3931181 A1, 1976 ;
反应条件
1: conc. HCl / ethanol / 2 h / Heating
2: diethyl ether / 3 h / Heating
3: aq. HCl / 0.17 h
4: 91 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C
5: 90 percent / propan-2-ol / 0.5 h / Heating
6: 92 percent / sodium methylate / ethanol / 40 h / Heating
View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
1: diethyl ether / 3 h / Heating
2: aq. HCl / 0.17 h
3: 91 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C
4: 90 percent / propan-2-ol / 0.5 h / Heating
5: 92 percent / sodium methylate / ethanol / 40 h / Heating
View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
1: 91 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C
2: 90 percent / propan-2-ol / 0.5 h / Heating
3: 92 percent / sodium methylate / ethanol / 40 h / Heating
View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
反应条件
1: 90 percent / propan-2-ol / 0.5 h / Heating
2: 92 percent / sodium methylate / ethanol / 40 h / Heating
View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
