2-(9-溴壬基-1-氧基)四氢吡喃合成路线 （共 19 条）
反应条件
1: HBr / toluene / 18 h / Heating
2: 3 h
View Scheme
参考文献
Naka, Hideshi; Nakazawa, Tomotake; Sugie, Mieko; Yamamoto, Masanobu; Horie, Yoshiteru; Wakasugi, Ryohei; Arita, Yutaka; Sugie, Hajime; Tsuchida, Koji; Ando, Tetsu
Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 2 p. 508 - 516
反应条件
hydrogen; platinum(IV) oxide
5 h;
参考文献
Iriye, Ryozo; Toya, Tsutomu; Makino, Junji; Aruga, Ryuichi; Doi, Yukio; et al.
Agricultural and Biological Chemistry, 1988 , vol. 52, # 4 p. 989 - 996
反应条件
1: sodium bromide / N,N-dimethyl-formamide / 3 h / 50 °C
2: toluene-4-sulfonic acid / dichloromethane / 0.33 h / 20 °C
View Scheme
参考文献
Kudo, Fumitaka; Asou, Yusaku; Watanabe, Moe; Kitayama, Takashi; Eguchi, Tadashi
Synlett, 2012 , vol. 23, # 12 p. 1843 - 1846
反应条件
1: 45 percent / Heating
2: 1.) n-BuLi / 1.) THF, DMSO, hexane, RT, 30 min, 2.) THF, DMSO, hexane, RT, 3 h
3: 100 percent / H2 / PtO2 / methanol / Ambient temperature
View Scheme
参考文献
Carballeira, Nestor; Thompson, Janice E.; Ayanoglu, Eser; Djerassi, Carl
Journal of Organic Chemistry, 1986 , vol. 51, # 14 p. 2751 - 2756
反应条件
1.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.5 h / -60 °C
1.2: -20 - 20 °C
2.1: Jone's reagent / acetone / 0 - 4 °C
3.1: sulfuric acid / 20 °C
View Scheme
参考文献
Fu, Yu; Weng, Yue; Hong, Wen-Xu; Zhang, Qinghai
Synlett, 2011 , # 6 p. 809 - 812
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0°C; 3 h;
参考文献
Nakamura, Tsuyoshi; Yonesu, Kiyoaki; Mizuno, Yumiko; Suzuki, Chie; Sakata, Yuki; Takuwa, Yoh; Nara, Futoshi; Satoh, Susumu
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 10 p. 3548 - 3564
反应条件
1.1: iodine; magnesium / tetrahydrofuran / 5.33 h / 20 °C / |Inert atmosphere; |Reflux
1.2: 12 h / 20 - 80 °C / |Ionic liquid
2.1: pyridinium p-toluenesulfonate / methanol / 50 °C
3.1: triphenylphosphine; carbon tetrabromide / dichloromethane / -10 °C
View Scheme
参考文献
Zhang, Tao; Ma, Wei-Li; Li, Tian-Rui; Wu, Jia; Wang, Jun-Run; Du, Zhen-Ting
Molecules, 2013 , vol. 18, # 5 p. 5201 - 5208
反应条件
1: hexamethylphosphoric acid triamide / 8 h / Ambient temperature
2: pyridinium p-toluenesulfonate / tetrahydrofuran; ethanol / 48 h / 55 - 60 °C
3: lithium aluminum hydride / tetrahydrofuran / 8 h / Heating
View Scheme
参考文献
Iriye, Ryozo; Toya, Tsutomu; Makino, Junji; Aruga, Ryuichi; Doi, Yukio; et al.
Agricultural and Biological Chemistry, 1988 , vol. 52, # 4 p. 989 - 996
反应条件
1: 50 percent / Mg, LiCl, CuCl2 / tetrahydrofuran
2: 82 percent / PTS / methanol / 3 h / Heating
3: 70 percent / pyridine / 24 h / Ambient temperature
View Scheme
参考文献
Vig, O. P.; Sharma, M. L.; Sabharwal, Arun; Rashmi; Huq, M. A.
Journal of the Indian Chemical Society, 1988 , vol. 65, p. 671 - 672
