2-(2-溴乙基硫代)-噻吩合成路线 （共 3 条）
反应条件
potassium carbonate
T=20 - 78°C; Inert atmosphere;
参考文献
BASILEA PHARMACEUTICA AG; GAUCHER, Berangere; DANEL, Franck, Hubert; TANG, XiaoHu; XIE, Tong; XU, Lin
Patent: WO2011/73378 A1, 2011 ;
Location in patent: Page/Page column 77-78 ;
反应条件
in sodium hydrogencarbonate; ethyl acetate; acetonitrile
参考文献
Baque, Eric; Carry, Jean-Christophe; El-Ahmad, Youssef; Evers, Michel; Hubert, Philippe; Malleron, Jean-Luc; Mignani, Serge; Pantel, Guy; Tabart, Michel; Viviani, Fabrice
Patent: US2002/111492 A1, 2002 ;
反应条件
1: thiophene With n-butyllithium in diethyl ether; hexane
T=-40°C; 1 h; Inert atmosphere;
2: With sulfur in diethyl ether; hexane
T=-78 - 0°C; Inert atmosphere;
3: ethylene dibromide in diethyl ether; hexane
T=0 - 20°C; 18 h; Inert atmosphere;
参考文献
Wiles, Jason A.; Phadke, Avinash S.; Bradbury, Barton J.; Pucci, Michael J.; Thanassi, Jane A.; Deshpande, Milind
Journal of Medicinal Chemistry, 2011 , vol. 54, # 9 p. 3418 - 3425
