1: With thionyl chloride; tetrabutyl-ammonium chloride in toluene
T=85°C;
2: With potassium carbonate in water
T=5°C; pH=11; Title compound not separated from byproducts;
参考文献
Amato, Joseph S.; Chung, John Y. L.; Cvetovich, Raymond J.; Gong, Xiaoyi; McLaughlin, Mark; Reamer, Robert A.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1930 - 1933
1.1: 1-chloroethyl chloroformate / 1,2-dichloro-ethane / 3 h / 80 °C
1.2: NaBr / methanol / 18 h / 20 °C
2.1: 89 percent / acetonitrile / 18 h / 73 °C
3.1: tetrahydrofuran / 8 h / -15 - 20 °C
View Scheme
参考文献
Amato, Joseph S.; Chung, John Y. L.; Cvetovich, Raymond J.; Gong, Xiaoyi; McLaughlin, Mark; Reamer, Robert A.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1930 - 1933
Amato, Joseph S.; Chung, John Y. L.; Cvetovich, Raymond J.; Gong, Xiaoyi; McLaughlin, Mark; Reamer, Robert A.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1930 - 1933
→
反应条件
in tetrahydrofuran
T=25°C;
参考文献
Amato, Joseph S.; Chung, John Y. L.; Cvetovich, Raymond J.; Gong, Xiaoyi; McLaughlin, Mark; Reamer, Robert A.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1930 - 1933
