4-溴甲基-3-硝基苯甲酸合成路线 （共 17 条）
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
参考文献
Lopes, Marcela S.; De Souza Pietra, Renata C.C.; Borgati, Tatiane F.; Romeiro, Carla F.D.; Junior, Policarpo A.S.; Romanha, Alvaro J.; Alves, Ricardo J.; Souza-Fagundes, Elaine M.; Fernandes, Ana Paula S.M.; De Oliveira, Renata B.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5443 - 5447
反应条件
in methanol; benzene
Ambient temperature;
参考文献
Tremblay, Martin R.; Poirier, Donald
Tetrahedron Letters, 1999 , vol. 40, # 7 p. 1277 - 1280
反应条件
1: 91 percent / Na2CO3, H2O / acetone / 12 h / Heating
2: 83 percent / BF3*OEt2 / 15 h / Heating
View Scheme
参考文献
Berteina, Sabine; De Mesmaeker, Alain
Synlett, 1998 , # 11 p. 1227 - 1230
反应条件
hydrogenchloride; sodium acetate
1.) acetic acid, reflux, 24 h; 2.) acetic acid, reflux; Yield given. Multistep reaction;
参考文献
Zehavi, Uri; Sadeh, Shoshana; Herchman, Mina
Carbohydrate Research, 1983 , vol. 124, p. 23 - 34
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1533304 A1, 2005 ;
Location in patent: Page/Page column 28 ;
EP 1533304 A1
反应条件
triethylamine; p-toluenesulfonyl chloride
0.0833333 h; Neat (no solvent);
参考文献
Soares, Giselle Apicela; De Oliveira, Renata Barbosa; De Andrade, Saulo Fernandes; Alves, Ricardo Jose; Zani, Carlos Leomar; De Souza-Fagundes, Elaine Maria
Molecules, 2010 , vol. 15, # 1 p. 12 - 26
反应条件
1: HCl / 18 h / 20 °C
2: DIEA / dimethylformamide / 18 h / 20 °C
3: CH2Cl2 / 18 h / 20 °C
4: H2 / Pd / tetrahydrofuran; methanol / 72 h / 20 °C / 760 Torr
5: toluene / Heating
6: potassium trimethylsilanolate / tetrahydrofuran / 2 h / 40 °C
View Scheme
参考文献
Hone, Neal D.; Wilson, William; Reader, John C.
Tetrahedron Letters, 2003 , vol. 44, # 46 p. 8493 - 8495
