2,6-二氯-3-硝基苯甲酸合成路线 （共 21 条）
反应条件
sulfuric acid; nitric acid 1 h; Heating;
参考文献
Dunstan, Mark S.; Barnes, John; Humphries, Matthew; Whitehead, Roger C.; Bryce, Richard A.; Leys, David; Stratford, Ian J.; Nolan, Karen A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6597 - 6611
反应条件
1: potassium acetate; ethanol / Erwaermen des Reaktionsprodukts mit wss. Natronlauge und Behandeln des Reaktionsgemisches mit Kaliumpermanganat 2: concentrated sulfuric acid; nitric acid View Scheme
参考文献
Chemische Berichte, , vol. 70, p. 1526,1531
参考文献
Chemische Berichte, , vol. 70, p. 1526,1531
反应条件
1: 47 percent / N,N-dimethylaniline, N,N-diisopropylethylamine / 18 h / Heating 2: 62 percent / N,N-dimethylaniline, POCl3 / CHCl3 / 1.5 h / Heating 3: 84 percent / methanesulfonic acid / acetic acid / 8 h / Heating 4: methanol / 120 h / Ambient temperature View Scheme
参考文献
Capps, David B.; Dunbar, James; Kesten, Suzanne R.; Shillis, Joan; Werbel, Leslie M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4770 - 4778
反应条件
1: 97 percent / ethanol; H2O / 2 h / Heating 2: 88 percent / 18percent aq. HCl View Scheme
参考文献
Romanowski, Jacek; Eckstein, Zygmunt
Polish Journal of Chemistry, 1984 , vol. 58, # 1-3 p. 263 - 268
参考文献
Lehmstedt; Schrader
Chemische Berichte, 1937 , vol. 70, p. 1526,1531
反应条件
1: 72 percent / 7 h / 110 °C 2: 82 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Cholody; Martelli; Konopa
Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2852 - 2856
反应条件
1: 68 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) 25 deg C, 12 h 2: 95 percent / trifluoroacetic anhydride, trifluoroacetic acid / 18 h / Ambient temperature 3: 1.) AlCl3, 2.) conc. HCl / 1.) dichloroethane, reflux, 1.5 h, 2.) reflux, 4 h View Scheme
参考文献
Hollis Showalter; Angelo; Berman; Kanter; Ortwine; Ross-Kesten; Sercel; Turner; Werbel; Worth; Elslager; Leopold; Shillis
Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1527 - 1539
反应条件
1.1: N,N-dimethyl-aniline / Inert atmosphere 2.1: trichlorophosphate / 1,2-dichloro-ethane / 90 °C 3.1: N,N-dimethyl-formamide / 4 h / Reflux 4.1: hydrazine hydrate / tetrahydrofuran / 24 h / 20 °C 4.2: 0.5 h / pH 3 5.1: 24 h / Reflux View Scheme
参考文献
Dunstan, Mark S.; Barnes, John; Humphries, Matthew; Whitehead, Roger C.; Bryce, Richard A.; Leys, David; Stratford, Ian J.; Nolan, Karen A.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6597 - 6611
反应条件
borane-THF in tetrahydrofuran 48 h; Heating / reflux;
参考文献
Yamada, Tatsuhiro; Nakagawa, Tadakiyo; Tanaka, Yasuhiro; Fujita, Kohichi; Tagami, Tomoyuki; Ikenoue, Yuka; Fukuda, Shunsuke; Chujo, Yoshitomo; Suzuki, Manabu; Murata, Masahiro
Patent: US2005/250796 A1, 2005 ;
Location in patent: Page/Page column 13 ;
