4-溴-2,5-二甲氧基-苯酚合成路线 （共 4 条）
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in dichloromethane
T=25°C; Baeyer-Villiger oxidation; 4 h;
2: With sodium hydroxide in methanol
T=25°C; 1 h;
参考文献
Tisdale, Eric J.; Kochman, David A.; Theodorakis, Emmanuel A.
Tetrahedron Letters, 2003 , vol. 44, # 16 p. 3281 - 3284
反应条件
1.1: 45 percent / Br2 / acetic acid / 4 h / 25 °C
2.1: m-CPBA / CH2Cl2 / 4 h / 25 °C
2.2: 99 percent / aq. NaOH / methanol / 1 h / 25 °C
View Scheme
参考文献
Tisdale, Eric J.; Kochman, David A.; Theodorakis, Emmanuel A.
Tetrahedron Letters, 2003 , vol. 44, # 16 p. 3281 - 3284
反应条件
1: 84 percent / DBU; CuCl2 / acetonitrile / 6 h / 0 °C
2: cerium ammonium nitrate / acetonitrile; H2O / 0.5 h / 25 °C
3: PhCH3 / 0.5 h / 40 °C
4: NaBH4; AcOH / tetrahydrofuran / 0.5 h / 25 °C
5: DIPEA / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Tisdale, Eric J.; Kochman, David A.; Theodorakis, Emmanuel A.
Tetrahedron Letters, 2003 , vol. 44, # 16 p. 3281 - 3284
反应条件
1: 84 percent / DBU; CuCl2 / acetonitrile / 6 h / 0 °C
2: cerium ammonium nitrate / acetonitrile; H2O / 0.5 h / 25 °C
3: PhCH3 / 0.5 h / 40 °C
View Scheme
参考文献
Tisdale, Eric J.; Kochman, David A.; Theodorakis, Emmanuel A.
Tetrahedron Letters, 2003 , vol. 44, # 16 p. 3281 - 3284
