4-(N-己基氨基)苯甲酸合成路线 （共 9 条）
反应条件
1: With methanol; sodium hydroxide; water
T=50°C; 24 h;
2: With hydrogenchloride in water
T=0°C;
参考文献
TANABE SEIYAKU CO., LTD.
Patent: WO2006/80477 A1, 2006 ;
Location in patent: Page/Page column 30; 55 ;
反应条件
potassium hydroxide in ethanol
5 h; Heating;
参考文献
Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393
反应条件
potassium hydroxide; biphenyl-2-yl-di-tert-butyl-phosphane; palladium diacetate in toluene
T=100°C; Buchwald-Hartwig amination; 0.5 h; microwave irradiation;
参考文献
Van Baelen, Gitte; Maes, Bert U.W.
Tetrahedron, 2008 , vol. 64, # 23 p. 5604 - 5619
反应条件
Josiphos ligand; lithium hexamethyldisilazane; palladium diacetate in ethylene glycol dimethyl ether
T=100°C;
参考文献
Strassmaier, Timothy; Kirk, Sarah R.; Banerji, Tapasree; Karpen, Jeffrey W.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 645 - 649
反应条件
1: 53 percent / hexamethylphosphoric acid triamide / 24 h / 125 °C
2: 87 percent / KOH / aq. ethanol / 5 h / Heating
View Scheme
参考文献
Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393
反应条件
1: ethanol / 0.17 h / cooling
2: 76.7 g / sodium cyanotrihydroborate / ethanol / 12 h / 20 °C
View Scheme
参考文献
Koenig, Hannah M.; Abbel, Robert; Schollmeyer, Dieter; Kilbinger, Andreas F. M.
Organic Letters, 2006 , vol. 8, # 9 p. 1819 - 1822
反应条件
1: ethanol / 0.17 h / cooling
2: 76.7 g / sodium cyanotrihydroborate / ethanol / 12 h / 20 °C
View Scheme
参考文献
Koenig, Hannah M.; Abbel, Robert; Schollmeyer, Dieter; Kilbinger, Andreas F. M.
Organic Letters, 2006 , vol. 8, # 9 p. 1819 - 1822
反应条件
1: 53 percent / hexamethylphosphoric acid triamide / 24 h / 125 °C
2: 87 percent / KOH / aq. ethanol / 5 h / Heating
View Scheme
参考文献
Albright; DeVries; Largis; Miner; Reich; Schaffer; Shepherd; Upeslacis
Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1378 - 1393
参考文献
Stelt et al.
Leeuwenhoek J. Microbiol. Serol., 1954 , vol. 20, p. 285,293
