2,3,4,5-四氟硝基苯合成路线 （共 21 条）
反应条件
t-Bu-XantPhos; tBuXantphosAu(AuCl2); (Ph)2SiH2; acetic acid in 1,2-dichloro-ethane T=80°C; 24 h; Inert atmosphere;
参考文献
Lv, Hongbin; Cai, Yuan-Bo; Zhang, Jun-Long
Angewandte Chemie - International Edition, 2013 , vol. 52, # 11 p. 3203 - 3207
Angew. Chem., 2013 , vol. 125, # 11 p. 3285 - 3289,5
反应条件
4-(N,N-dimethlyamino)pyridine; C21H27AuN2 in dichloromethane T=40°C; 12 h; Inert atmosphere;
参考文献
Lv, Hongbin; Zhan, Jin-Hui; Cai, Yuan-Bo; Yu, Yi; Wang, Bingwu; Zhang, Jun-Long
Journal of the American Chemical Society, 2012 , vol. 134, # 39 p. 16216 - 16227,12
反应条件
1: Sn, aq. HCl 2: Br2 / Heating 3: aq. H2SO4 / Heating 4: dimethylformamide / Heating 5: aq. H2O2, (CF3CO)2O / CH2Cl2 / Heating 6: H2SO4 7: aq. H2SO4 View Scheme
参考文献
Belf,L.J. et al.
Tetrahedron, 1967 , vol. 23, p. 4719 - 4727
反应条件
ammonia in tetrahydrofuran T=20°C; 16 h; Sealed tube;
参考文献
SCIFLUOR LIFE SCIENCES, LLC; Duggan, Mark E.; Furuya, Takeru; Edwards, D. Scott; Purohit, Ajay
Patent: US2013/287686 A1, 2013 ;
Location in patent: Paragraph 0148; 0149 ;
反应条件
1: Sn, aq. HCl 2: (i) nBuLi, hexane, THF, (ii) /BRN= 1900390/ View Scheme
参考文献
Belf,L.J. et al.
Tetrahedron, 1967 , vol. 23, p. 4719 - 4727
反应条件
XeF2; hydrogen fluoride
0.416667 h; Ambient temperature; Further byproducts given. Title compound not separated from byproducts;
参考文献
Bardin; Shchegoleva; Frohn
Journal of Fluorine Chemistry, 1996 , vol. 77, # 2 p. 153 - 159
反应条件
XeF2; hydrogen fluoride
0.416667 h; Ambient temperature; Further byproducts given. Title compound not separated from byproducts;
参考文献
Bardin; Shchegoleva; Frohn
Journal of Fluorine Chemistry, 1996 , vol. 77, # 2 p. 153 - 159
反应条件
N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one
T=-20°C; regioselective reaction;
参考文献
Kim, Ji-Young; Boyer, Frederick E.; Choy, Allison L.; Huband, Michael D.; Pagano, Paul J.; Vara Prasad
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 550 - 553
反应条件
1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / -20 °C
2: hydrogen / tetrahydrofuran / 2585.81 Torr
View Scheme
参考文献
Kim, Ji-Young; Boyer, Frederick E.; Choy, Allison L.; Huband, Michael D.; Pagano, Paul J.; Vara Prasad
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 550 - 553
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=40°C; 18 h;
参考文献
PHARMACIA and UPJOHN COMPANY LLC
Patent: WO2007/4049 A1, 2007 ;
Location in patent: Page/Page column 41-42 ;
