2,3,4,5-四氟苯胺合成路线 （共 19 条）
反应条件
1: Br2 / Heating 2: aq. H2SO4 / Heating 3: dimethylformamide / Heating 4: aq. H2O2, (CF3CO)2O / CH2Cl2 / Heating 5: H2SO4 6: aq. H2SO4 View Scheme
参考文献
Belf,L.J. et al.
Tetrahedron, 1967 , vol. 23, p. 4719 - 4727
反应条件
1: (i) NaNO2, aq. HCl, (ii) aq. KI 2: Cu / 200 °C 3: HNO3 View Scheme
参考文献
Namkung,M.J.; Fletcher,T.L.
Canadian Journal of Chemistry, 1967 , vol. 45, p. 2569 - 2575
反应条件
1: (i) NaNO2, aq. HCl, (ii) aq. KI 2: Cu / 200 °C 3: HNO3 4: SnCl2*2H2O, aq. HCl View Scheme
参考文献
Namkung,M.J.; Fletcher,T.L.
Canadian Journal of Chemistry, 1967 , vol. 45, p. 2569 - 2575
反应条件
1: (i) NaNO2, aq. HCl, (ii) aq. KI 2: Cu / 200 °C View Scheme
参考文献
Namkung,M.J.; Fletcher,T.L.
Canadian Journal of Chemistry, 1967 , vol. 45, p. 2569 - 2575
反应条件
1: Br2 / Heating 2: aq. H2SO4 / Heating 3: dimethylformamide / Heating 4: H2SO4 5: aq. NaOH / Heating View Scheme
参考文献
Belf,L.J. et al.
Tetrahedron, 1967 , vol. 23, p. 4719 - 4727
反应条件
(i) nBuLi, hexane, THF, (ii) /BRN= 1900390/; Multistep reaction;
参考文献
Belf,L.J. et al.
Tetrahedron, 1967 , vol. 23, p. 4719 - 4727
反应条件
in toluene
1 h; Heating;
参考文献
Popp
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 6 p. 1641 - 1645
反应条件
1: Br2, Fe, NaOAc / acetic acid
2: aq. H2O2, (CF3CO)2O / CH2Cl2
View Scheme
参考文献
Yakobson,G.G. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1967 , vol. 37, # 6 p. 1289 - 1293,1221 - 1224
反应条件
sulfuric acid; m-nitrobenzene sulfonic acid sodium salt
T=140°C; Condensation; cyclization; 4 h;
参考文献
Kato, Taka-Aki; Saeki, Ken-Ichi; Kawazoe, Yutaka; Hakura, Atsushi
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 1999 , vol. 439, # 2 p. 149 - 157
