2-氨基-1-苄基-4,5-二苯基-1H-吡咯-3-甲腈合成路线 (共 3 条)
反应条件
1: 1,2-diphenyl-2-hydroxyethanone; benzylamine With zinc(II) chloride Knoevenagel Condensation; 3 h; Reflux; 2: malononitrile in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF KANSAS; NORTHWESTERN UNIVERSITY; FRANKOWSKI, Kevin; PATNAIK, Samarjit; HUANG, Sui; MARUGAN, Juan Jose; NORTON, John; SCHOENEN, Frank J.; SOUTHALL, Noel; TITUS, Steven; ZHENG, Wei
Patent: WO2013/90912 A1, 2013 ;
Location in patent: Paragraph 0093 ;
反应条件
in toluene 24 h; RefluxInert atmosphere;
参考文献
Coumar, Mohane Selvaraj; Tsai, Ming-Tsung; Chu, Chang-Ying; Uang, Biing-Jiun; Lin, Wen-Hsing; Chang, Chun-Yu; Chang, Teng-Yuan; Leou, Jiun-Shyang; Teng, Chi-Huang; Wu, Jian-Sung; Fang, Ming-Yu; Chen, Chun-Hwa; Hsu, John T.-A.; Wu, Su-Ying; Chao, Yu-Sheng; Hsieh, Hsing-Pang
ChemMedChem, 2010 , vol. 5, # 2 p. 255 - 267
反应条件
1: 5 h / 110 °C 2: POCl3 / 2.5 h / Heating View Scheme
参考文献
Hussein, Waleed M.; Fatahala, Samar S.; Mohamed, Zainab M.; Mcgeary, Ross P.; Schenk, Gerhard; Ollis, David L.; Mohamed, Mosaad S.
Chemical Biology and Drug Design, 2012 , vol. 80, # 4 p. 500 - 515