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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
55827-09-3
合成路线
（共 13 条）
3141-27-3
2,5-二溴噻吩
+
5720-07-0
4-甲氧基苯硼酸
→
反应条件
55827-09-3
反应条件
palladium diacetate; sodium carbonate; triphenylphosphine in water; toluene T=120°C; Suzuki Coupling; 24 h; Inert atmosphere;
参考文献
Min, Jian; Wang, Pengcheng; Srinivasan, Sathish; Nwachukwu, Jerome C.; Guo, Pu; Huang, Minjian; Carlson, Kathryn E.; Katzenellenbogen, John A.; Nettles, Kendall W.; Zhou, Hai-Bing
Journal of Medicinal Chemistry, 2013 , vol. 56, # 8 p. 3346 - 3366
188290-36-0
+
696-62-8
4-碘苯甲醚
→
反应条件
42545-43-7
2-(4-甲氧苯基)噻吩
+
55827-09-3
反应条件
silver fluoride; PdCl2(PPh2(CH2)4PPh2) in dimethyl sulfoxide T=60°C; 5 h;
参考文献
Masui, Kentaro; Mori, Atsunori; Okano, Kunihiko; Takamura, Kenji; Kinoshita, Motoi; Ikeda, Tomiki
Organic Letters, 2004 , vol. 6, # 12 p. 2011 - 2014
696-62-8
4-碘苯甲醚
+
133752-62-2
→
反应条件
55827-09-3
反应条件
bis-triphenylphosphine-palladium(II) chloride; diisobutylaluminium hydride in tetrahydrofuran; diethyl ether; hexane 1 h;
参考文献
Takahashi, Kazuko; Suzuki, Tsuyoshi; Akiyama, Kimio; Ikegami, Yusaku; Fukazawa, Yosbimasa
Journal of the American Chemical Society, 1991 , vol. 113, # 12 p. 4576 - 4583
→
反应条件
55827-09-3
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; silver(l) oxide in methanol T=20°C; Suzuki-Miyaura cross- coupling; 1.5 h; Inert atmosphere;
参考文献
Botteselle, Giancarlo V.; Hough, Thomas L. S.; Venturoso, Raphael C.; Cella, Rodrigo; Vieira, Adriano S.; Stefani, Helio A.
Australian Journal of Chemistry, 2008 , vol. 61, # 11 p. 870 - 873
188290-36-0
+
104-92-7
4-溴苯甲醚
→
反应条件
42545-43-7
2-(4-甲氧苯基)噻吩
+
55827-09-3
反应条件
1: thiophene With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; CdCl2*TMEDA in tetrahydrofuran; hexane T=0 - 20°C; Inert atmosphere; 2: 1-bromo-4-methoxy-benzene With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate in tetrahydrofuran; hexane 18 h; Inert atmosphereReflux; chemoselective reaction;
参考文献
Snegaroff, Katia; L'Helgoual'ch, Jean-Martial; Bentabed-Ababsa, Ghenia; Nguyen, Tan Tai; Chevallier, Floris; Yonehara, Mitsuhiro; Uchiyama, Masanobu; Derdour, Aicha; Mongin, Florence
Chemistry - A European Journal, 2009 , vol. 15, # 39 p. 10280 - 10290
17284-07-0
→
反应条件
55827-09-3
反应条件
hydrogenchloride in 1,4-dioxane 2 h;
参考文献
Schroth, Werner; Dunger, Simona; Billig, Frank; Spitzner, Roland; Herzschuh, Rainer; Vogt, Almut; Jende, Thomas; Israel, Gunter; Barche, Jens; Stroehl, Dieter; Sieler, Joachim
Tetrahedron, 1996 , vol. 52, # 39 p. 12677 - 12698
104-92-7
4-溴苯甲醚
→
反应条件
55827-09-3
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=100°C; 24 h;
参考文献
Bayly; Humphrey; De Chair; Paredes; Bell; Jeffery; McCleverty; Ward; Totti; Gatteschi; Courric; Steele; Screttas
Journal of the Chemical Society, Dalton Transactions, 2001 , # 9 p. 1401 - 1414
54095-24-8
2-溴-5-(4-甲氧基苯基)噻吩
+
5720-07-0
4-甲氧基苯硼酸
→
反应条件
55827-09-3
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in tetrahydrofuran; water Suzuki coupling; 20 h; Inert atmosphereReflux;
参考文献
Bey, Emmanuel; Marchais-Oberwinkler, Sandrine; Werth, Ruth; Negri, Matthias; Al-Soud, Yaseen A.; Kruchten, Patricia; Oster, Alexander; Frotscher, Martin; Birk, Barbara; Hartmann, Rolf W.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6725 - 6739
16212-90-1
→
反应条件
55827-09-3
反应条件
1: KOH / dimethylformamide / 1.5 h / 50 - 60 °C 2: 50 percent / HCl(gas) / dioxane / 2 h View Scheme
参考文献
Schroth, Werner; Dunger, Simona; Billig, Frank; Spitzner, Roland; Herzschuh, Rainer; Vogt, Almut; Jende, Thomas; Israel, Gunter; Barche, Jens; Stroehl, Dieter; Sieler, Joachim
Tetrahedron, 1996 , vol. 52, # 39 p. 12677 - 12698
22779-05-1
→
反应条件
55827-09-3
反应条件
1: aq. KOH, 18-crown-6 / benzene / 5 h / Heating 2: KOH / dimethylformamide / 1.5 h / 50 - 60 °C 3: 50 percent / HCl(gas) / dioxane / 2 h View Scheme
参考文献
Schroth, Werner; Dunger, Simona; Billig, Frank; Spitzner, Roland; Herzschuh, Rainer; Vogt, Almut; Jende, Thomas; Israel, Gunter; Barche, Jens; Stroehl, Dieter; Sieler, Joachim
Tetrahedron, 1996 , vol. 52, # 39 p. 12677 - 12698
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