4-咪唑并[1,2-a]吡啶-2-苯甲腈合成路线 （共 11 条）
反应条件
diisobutylaluminium hydride in hexane; toluene 1 h; Ambient temperature;
参考文献
Sundberg; Dahlhausen; Manikumar; Mavunkel; Biswas; Srinivasan; King Jr.; Waid
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 1 p. 129 - 137
反应条件
copper(l) iodide; oxygen in N,N-dimethyl-formamide
T=110°C; P=760.051 Torr; 36 h; Schlenk techniqueSealed tubeGreen chemistry;
参考文献
Yu, Jipan; Jin, Yunhe; Zhang, Hao; Yang, Xiaobo; Fu, Hua
Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16804 - 16808
反应条件
indium trifluoromethanesulfonate; copper(l) iodide; oxygen in 1-methyl-pyrrolidin-2-one
T=100°C; P=760.051 Torr; 30 h; Schlenk technique;
参考文献
Zhang, Yuhong; Zhang, Yuanfei; Chen, Zhengkai; Wu, Wenliang; Su, Weiping
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12494 - 12504
反应条件
sodium hydrogencarbonate in ethanol
10 h; Heating / reflux;
参考文献
Fujifilm RI Pharma Co., Ltd.; Daiichi Sankyo Company, Limited
Patent: EP1956013 A1, 2008 ;
Location in patent: Page/Page column 42 ;
反应条件
potassium fluoride in N,N-dimethyl-formamide
T=20 - 130°C; 12.1667 h; Inert atmosphere; regioselective reaction;
参考文献
Liu, Guoping; Cong, Xuefeng; He, Jiaheng; Luo, Shunzhong; Wu, Di; Lan, Jingbo
Journal of Chemical Research, 2012 , vol. 36, # 12 p. 687 - 690
反应条件
in N,N-dimethyl-formamide
48 h; Heating;
参考文献
Sundberg, Richard J.; Biswas, Sujay; Murthi, Krishna Kumar; Rowe, Donna; McCall, John W.; Dzimianski, Michael T.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4317 - 4328
反应条件
anhydrous iron chloride; tetra-(n-butyl)ammonium iodide
T=90°C; 4 h;
参考文献
Yan, Hao; Wang, Yuling; Pan, Congming; Zhang, Hao; Yang, Sizhuo; Ren, Xiaoyu; Li, Jian; Huang, Guosheng
European Journal of Organic Chemistry, 2014 , vol. 2014, # 13 p. 2754 - 2763
反应条件
1: 2.) 48percent HBr / 1.) acetone, reflux, 12 h, 2.) MeOH, reflux, 2 h
2: 72 percent / dimethylformamide / 48 h / Heating
View Scheme
参考文献
Sundberg, Richard J.; Biswas, Sujay; Murthi, Krishna Kumar; Rowe, Donna; McCall, John W.; Dzimianski, Michael T.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4317 - 4328
反应条件
1: 2.) 48percent HBr / 1.) acetone, reflux, 12 h, 2.) MeOH, reflux, 2 h
2: 72 percent / dimethylformamide / 48 h / Heating
View Scheme
参考文献
Sundberg, Richard J.; Biswas, Sujay; Murthi, Krishna Kumar; Rowe, Donna; McCall, John W.; Dzimianski, Michael T.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4317 - 4328
反应条件
in N,N-dimethyl-formamide
24 h; Heating;
参考文献
Sundberg; Dahlhausen; Manikumar; Mavunkel; Biswas; Srinivasan; King Jr.; Waid
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 1 p. 129 - 137
