反应条件
1.1: n-BuLi / tetrahydrofuran / 3 h / 0 °C
1.2: 90 percent / trimethyl borate / tetrahydrofuran / -78 - 20 °C
2.1: 86 percent / Ba(OH)2*8H2O / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 2 h / Heating
3.1: 87 percent / NBS; NaHCO3; pyridine / acetone; H2O / -15 - 20 °C
4.1: DBU; pyridine / 12 h / 80 °C
4.2: acetic anhydride / 3 h / 80 °C
4.3: 22 mg / HBr / 2,2,2-trifluoro-ethanol / 14 h / 80 °C
View Scheme
参考文献
Carles, Lionel; Narkunan, Kesavaram; Penlou, Sebastien; Rousset, Laurence; Bouchu, Denis; Ciufolini, Marco A.
Journal of Organic Chemistry, 2002 , vol. 67, # 12 p. 4304 - 4308
