4-(三氟甲基)-1H-咪唑-5-羧酸乙酯合成路线 （共 3 条）
反应条件
in water T=130°C; 1 h;
参考文献
ELBION GMBH; WYETH
Patent: US2009/143361 A1, 2009 ;
Location in patent: Page/Page column 33 ;
US 20090143361 A1
反应条件
in water T=135°C; 2 h;
参考文献
Zuev, Dmitry; Vrudhula, Vivekananda M.; Michne, Jodi A.; Dasgupta, Bireshwar; Pin, Sokhom S.; Huang, Xiaohua Stella; Wu, Dedong; Gao, Qi; Zhang, Jie; Taber, Matthew T.; MacOr, John E.; Dubowchik, Gene M.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3669 - 3674
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol
T=20°C; 2 h;
参考文献
Chong, Pek; Sebahar, Paul; Youngman, Michael; Garrido, Dulce; Zhang, Huichang; Stewart, Eugene L.; Nolte, Robert T.; Wang, Liping; Ferris, Robert G.; Edelstein, Mark; Weaver, Kurt; Mathis, Amanda; Peat, Andrew
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10601 - 10609
