2-甲氧基-4-甲基-6-羟基嘧啶合成路线 （共 26 条）
参考文献
Journal of the American Chemical Society, , vol. 26, p. 456
反应条件
sodium amide in 1,2,3,4-tetrahydro-naphthalene 24 h; Heating;
参考文献
Botta, M.; Angelis, F. De; Finizia, G.; Gambacorta, A.; Nicoletti, R.
Synthetic Communications, 1985 , vol. 15, p. 27 - 34
反应条件
1: 95 percent / LiH / dioxane / 2 h / 60 °C 2: 98 percent / aq. HCl / dioxane / 2 h / 60 °C View Scheme
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
sulfuric acid in water T=70°C; 12 h; pH=2; Yield given;
参考文献
Botta, M.; Cavalieri, M.; Ceci, D.; Angelis, F. De; Finizia, G.; Nicoletti, R.
Tetrahedron, 1984 , vol. 40, # 17 p. 3313 - 3320
反应条件
T=90 - 100°C; das Hydrochlorid reagiert;
参考文献
Bruce
Journal of the American Chemical Society, 1904 , vol. 26, p. 456
反应条件
aluminium trichloride transmethylation, further Lewis acid;
参考文献
Tetrahedron Letters, , vol. 26, # 28 p. 3345 - 3348
参考文献
Botta, M.; Cavalieri, M.; Ceci, D.; Angelis, F. De; Finizia, G.; Nicoletti, R.
Tetrahedron, 1984 , vol. 40, # 17 p. 3313 - 3320
反应条件
sodium hydroxide
T=20°C; Methylation; hydrolysis; 1 h;
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
sodium hydroxide in 1,4-dioxane
T=20°C; Alkylation; hydrolysis; 12 h;
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
1: 48 percent / aq. NaOH / dioxane / 12 h / 20 °C
2: 98 percent / aq. HCl / dioxane / 2 h / 60 °C
View Scheme
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
