2-氨基-4,6-二氯嘧啶合成路线 （共 63 条）
反应条件
T=17°C; 4.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
DEGUSSA AG
Patent: WO2004/37795 A1, 2004 ;
Location in patent: Page/Page column 9 ;
反应条件
hydrogen fluoride T=50°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Fukuhara, Tsuyoshi; Yoneda, Norihiko
Chemistry Letters, 1993 , # 3 p. 509 - 512
反应条件
potassium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride in ethanol; water T=75 - 80°C; 2 - 11.5 h; Product distribution / selectivity;
参考文献
Burgoon, JR., Hugh Alfred; Kanamarlapudi, Ramanaiah C.; Pickersgill, Iain Fraser; Shi, Zhi-Cai; Wu, Wenxue; Zhang, Haiming
Patent: US2009/48280 A1, 2009 ;
Location in patent: Page/Page column 9; 13-14 ;
US 20090048280 A1
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) 3 h; Heating / reflux;
参考文献
Kyorin Pharmaceutical Co., Ltd.
Patent: EP1473295 A1, 2004 ;
Location in patent: Page 20 ;
反应条件
potassium carbonate in ethanol 18 h; Heating / reflux;
参考文献
US6677345 B1, ;
Page/Page column 12 ;
US 6677345 B1
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=50°C; 1.5 h;
参考文献
GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; BLACKLEDGE, Charles, William; BRADY, Gerald, Patrick; FENG, Yanhoug, G.; GRANT, Seth, W.; MEDINA, Jesus, Rahul; MILLER, William, H.; ROMERIL, Stuart, P.
Patent: WO2010/59658 A1, 2010 ;
Location in patent: Page/Page column 121 ;
WO 2010/059658 A1
反应条件
triethylamine in methanol T=50°C; 2 h;
参考文献
GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; BRADY, Gerald, Patrick, Jr.; GALLAGHER, Timothy, Francis; HEERDING, Dirk, A.; MEDINA, Jesus, Raul; ROMERIL, Stuart, Paul
Patent: WO2010/120854 A1, 2010 ;
Location in patent: Page/Page column 90 ;
WO 2010/120854 A1
参考文献
GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; BRADY, Gerald, Patrick, Jr.; GALLAGHER, Timothy, Francis; HEERDING, Dirk, A.; MEDINA, Jesus, Raul; ROMERIL, Stuart, Paul
Patent: WO2010/120854 A1, 2010 ;
Location in patent: Page/Page column 96 ;
WO 2010/120854 A1
反应条件
sodium hydroxide 1 h; Heating;
参考文献
Burgdorf, Lars T; Carell, Thomas
Chemistry (Weinheim an der Bergstrasse, Germany), 2002 , vol. 8, # 1 p. 293 - 301
参考文献
Smith; Christensen
Journal of Organic Chemistry, 1955 , vol. 20, p. 829,833,835
