2-氨基-4,6-二氯嘧啶合成路线

参考文献

Kang, Yanlong; Taldone, Tony; Patel, Hardik J.; Patel, Pallav D.; Rodina, Anna; Gozman, Alexander; Maharaj, Ronnie; Clement, Cristina C.; Patel, Maulik R.; Brodsky, Jeffrey L.; Young, Jason C.; Chiosis, Gabriela
Journal of Medicinal Chemistry, 2014 , vol. 57, # 4 p. 1188 - 1207

56-05-32-氨基-4,6-二氯嘧啶+

141-52-6乙醇钠

90154-00-0

参考文献

Rose; Tuey
Journal of the Chemical Society, 1946 , p. 81,84

56-05-32-氨基-4,6-二氯嘧啶+

100-46-9苄胺

91066-67-0N4-苄基-6-氯-2,4-嘧啶二胺

参考文献

Sander, Kerstin; Kottke, Tim; Tanrikulu, Yusuf; Proschak, Ewgenij; Weizel, Lilia; Schneider, Erich H.; Seifert, Roland; Schneider, Gisbert; Stark, Holger
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 20 p. 7186 - 7196

56-05-32-氨基-4,6-二氯嘧啶+

95-53-4邻甲苯胺

91066-68-1

参考文献

GLAXOSMITHKLINE LLC; AXTEN, Jeffrey, Michael; BRADY, Gerald, Patrick, Jr.; GALLAGHER, Timothy, Francis; HEERDING, Dirk, A.; MEDINA, Jesus, Raul; ROMERIL, Stuart, Paul
Patent: WO2010/120854 A1, 2010 ;
Location in patent: Page/Page column 151 ;
WO 2010/120854 A1

56-05-32-氨基-4,6-二氯嘧啶+

873-74-5对氨基苯腈

91183-10-7

参考文献

BAYER HEALTHCARE AG
Patent: WO2004/39796 A1, 2004 ;
Location in patent: Page/Page column 87-88 ;
WO 2004/039796 A1

56-05-32-氨基-4,6-二氯嘧啶+

104-94-9对甲氧基苯胺

91241-38-26-氯-N4-(4-甲氧基苯基)-2,4-嘧啶二胺

参考文献

Basford et al.
Journal of the Chemical Society, 1947 , p. 1354,1360

56-05-32-氨基-4,6-二氯嘧啶+

23722-89-6

91296-08-1

参考文献

Shealy, Y. Fulmer; O'Dell, C. Allen; Shannon, W. M.; Arnett, Gussie
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1416 - 1421

56-05-32-氨基-4,6-二氯嘧啶+

23722-89-6

91296-08-1

参考文献

Shealy, Y. Fulmer; O'Dell, C. Allen; Shannon, W. M.; Arnett, Gussie
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1416 - 1421

56-05-32-氨基-4,6-二氯嘧啶+

945978-63-2

945978-64-3

参考文献

Shi, Zhi-Cai; Devasagayaraj, Arokiasamy; Gu, Kunjian; Jin, Haihong; Marinelli, Brett; Samala, Lakshman; Scott, Sheldon; Stouch, Terry; Tunoori, Ashok; Wang, Ying; Zang, Yi; Zhang, Chengmin; Kimball, S. David; Main, Alan J.; Sun, Weimei; Yang, Qi; Nouraldeen, Amr; Yu, Xiang-Qing; Buxton, Eric; Patel, Shiv; Nguyen, Nghi; Swaffield, Jon; Powell, David R.; Wilson, Alan; Liu, Qingyun
Journal of Medicinal Chemistry, 2008 , vol. 51, # 13 p. 3684 - 3687

56-05-32-氨基-4,6-二氯嘧啶+

79200-57-0(1R,2S,3R,4R)-2,3-二羟基-4-(羟甲基)-1-氨基环戊烷水电氯化物

50619-38-0

参考文献

Kwong, Cecil D.; Clark, Jeremy L.; Fowler, Anita T.; Geng, Feng; Kezar III, Hollis S.; Roychowdhury, Abhijit; Reynolds, Robert C.; Maddry, Joseph A.; Ananthan, Subramaniam; Secrist III, John A.; Shih, Neng-Yang; Piwinski, John J.; Li, Cheng; Feld, Boris; Huang, Hsueh-Cheng; Tong, Xiao; George Njoroge; Arasappan, Ashok
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1160 - 1164