2,4-二氨基-6-羟基嘧啶合成路线 （共 21 条）
反应条件
triethylamine in methanol T=60°C; Rate constant;
参考文献
Terashima, Isamu; Kohda, Kohfuku
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 503 - 508
反应条件
sodium hydroxide in methanol; water T=20°C; Rate constant;
参考文献
Popova; Studentsov
Russian Journal of General Chemistry, 1997 , vol. 67, # 3 p. 435 - 438
反应条件
2,3-dimethyl aniline; trichlorophosphate
反应条件
in water; N,N-dimethyl-formamide T=20°C; 46 h;
参考文献
Klepper, Florian; Jahn, Eva-Maria; Hickmann, Volker; Carell, Thomas
Angewandte Chemie - International Edition, 2007 , vol. 46, # 13 p. 2325 - 2327
参考文献
Ohno, Hiroyuki; Terui, Takashi; Kitawaki, Takafumi; Chida, Noritaka
Tetrahedron Letters, 2006 , vol. 47, # 32 p. 5747 - 5750
反应条件
1: formic acid methyl ester; chloroacetonitrile With sodium methylate in tetrahydrofuran 2: 2,4-diamino-6-hydroxypyrimidine With sodium acetate in tetrahydrofuran; water Further stages.;
参考文献
Brueckl, Tobias; Klepper, Florian; Gutsmiedl, Katrin; Carell, Thomas
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 23 p. 3821 - 3825
反应条件
sodium hydroxide; trichlorophosphate 1.) 40 deg C, 1 h, 2.) reflux; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 20, # 9 p. 1805 - 1809
反应条件
1: 2,4-diamino-6-hydroxypyrimidine With sodium hydride in N,N-dimethyl-formamide; mineral oil 0.5 h; Inert atmosphere; 2: ethyl trifluoromethanesulphonate in N,N-dimethyl-formamide; mineral oil
参考文献
BAYER HEALTHCARE AG
Patent: US2010/35902 A1, 2010 ;
Location in patent: Page/Page column 20 ;
反应条件
hydrogenchloride; sodium acetate; sodium nitrite coupling: 20 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Belodedova, Zh. V.; Smorygo, N. A.; Mirzoyan, V. S.; Melik-Orandzhanyan, R. G.; Studentsov, E. P.; Ivin, B. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , p. 538 - 545
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 5 p. 659 - 667
反应条件
in methanol 6 h; Heating;
参考文献
Ladva; Dave; Parekh
Journal of the Indian Chemical Society, 1991 , vol. 68, # 6 p. 370 - 371
