2,4-二氨基-6-羟基嘧啶合成路线 （共 21 条）
反应条件
in methanol Heating;
参考文献
Ladva; Dave; Parekh
Journal of the Indian Chemical Society, 1991 , vol. 68, # 6 p. 370 - 371
反应条件
acetic acid; sodium nitrite in water T=80°C;
参考文献
De Jonghe, Steven; Marchand, Arnaud; Gao, Ling-Jie; Calleja, Agnes; Cuveliers, Eva; Sienaert, Ilse; Herman, Jean; Clydesdale, Gavin; Sefrioui, Hassane; Lin, Yuan; Pfleiderer, Wolfgang; Waer, Mark; Herdewijn, Piet
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 145 - 149
反应条件
sodium hydroxide in water; acetonitrile
参考文献
AZAD PHARMACEUTICAL INGREDIENTS AG; ALBRECHT, Uwe, Jens; HELMBOLDT, Hannes; NIKOLAEV, Vsevolod, Valiervich
Patent: WO2011/64256 A1, 2011 ;
Location in patent: Page/Page column 16-17 ;
反应条件
sodium hydroxide; potassium carbonate; trichlorophosphate in tetrahydrofuran; water; acetone
参考文献
ISTITUTO FARMACOLOGICO SERONO SpA
Patent: EP295218 A1, 1988 ;
反应条件
in ethylene glycol
T=140 - 160°C;
参考文献
Roth; Strelitz; Rauckmann
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 379 - 384
反应条件
hydrogenchloride; sodium acetate; sodium nitrite
coupling: 20 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Belodedova, Zh. V.; Smorygo, N. A.; Mirzoyan, V. S.; Melik-Orandzhanyan, R. G.; Studentsov, E. P.; Ivin, B. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , p. 538 - 545
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 5 p. 659 - 667
反应条件
in N,N-dimethyl-formamide
T=20°C; Condensation; 24 h;
参考文献
Gangjee; Dubash; Queener
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 4 p. 935 - 942
反应条件
trichlorophosphate
1.) 90 deg C, 10 h, 2.) reflux, 3 h; Yield given. Multistep reaction;
参考文献
Temple, Carroll; Elliott, Robert D.; Montgomery, John A.
Journal of Organic Chemistry, 1982 , vol. 47, # 5 p. 761 - 764
反应条件
sodium hydroxide; trichlorophosphate
1.) 40 deg C, 1 h, 2.) reflux; Yield given. Multistep reaction;
参考文献
Delia, Thomas J.; Otteman, Ronald
Heterocycles, 1983 , vol. 20, # 9 p. 1805 - 1809
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
T=20°C; 48 h;
参考文献
Hockova, Dana; Holy, Antonin; Masojidkova, Milena; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan
Journal of Medicinal Chemistry, 2003 , vol. 46, # 23 p. 5064 - 5073
