4-硝基喹啉-N-氧化物合成路线 （共 69 条）
反应条件
1: 79 percent / Fe; AcOH / 3 h / 110 °C 2: 82 percent / Br2; AcOH / 0.5 h / 20 °C View Scheme
参考文献
Shinkai; Ito; Iida; Kitao; Yamada; Uchida
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4667 - 4677
反应条件
1: hydrobromic acid / Heating 2: phosphorus trichloride 3: Heating 4: aq. base View Scheme
参考文献
Ono, Isao; Hata, Norisuke
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 8 p. 2891 - 2898
反应条件
ethanol; palladium Hydrogenation;
参考文献
Ochiai; Naito
Yakugaku Zasshi, 1944 , vol. 64, # 4 p. 209
Chem.Abstr., 1951 , p. 5154
参考文献
Ochiai et al.
Pharmaceutical Bulletin, 1957 , vol. 5, p. 310
Chem.Abstr., 1951 , p. 8527
参考文献
Ochiai; Kaneko
Pharmaceutical Bulletin, 1957 , vol. 5, p. 56,60
反应条件
ascorbic acid powder 2.) acetic acid; Multistep reaction;
参考文献
Demeunynck,M.; Tohme,N.; Lhomme,M.
Journal of the American Chemical Society, 1986 , vol. 108, p. 3539
反应条件
phosphorus oxytribromide in chloroform T=0°C; 2 h;
参考文献
UNIVERSITEIT LEIDEN; CAN-FITE BIOPHARMA LTD.; IJZERMAN, Adriaan; GOBLYOS, Aniko; BRUSSEE, Johannes
Patent: WO2010/20981 A1, 2010 ;
Location in patent: Page/Page column 28-29; 1/2 ;
反应条件
phosphorus tribromide in chloroform T=20°C;
参考文献
Shmoilova; Dyablo; Pozharskii
Chemistry of Heterocyclic Compounds, 2013 , vol. 49, # 9 p. 1308 - 1322
Khim. Geterotsikl. Soedin., 2013 , vol. 49, # 9 p. 1404 - 1419,15
反应条件
phosphorus tribromide 0.5 h; Ambient temperature;
参考文献
Wozniak, Marian; Grzegozek, Maria
Chemistry of Heterocyclic Compounds, 1998 , vol. 34, # 7 p. 837 - 840
参考文献
Hamana et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 1337,1340
Chem.Abstr., 1957 , p. 6639
