1: N-carbobenzoxy-L-alanine With 1,2,2-trichloro-1,1,2-trichloro-ethane; triphenylphosphine in tetrahydrofuran T=0°C; 1.5 h; 2: (2S-trans)-L-glutamine With potassium hydroxide in tetrahydrofuran; dichloromethane; water T=0°C; pH=13; 2 h; 3: With sulfuric acid; hydrogen Product distribution / selectivity; more than 3 stages;
1: pivaloyl-alanine With 1,2,2-trichloro-1,1,2-trichloro-ethane; triphenylphosphine in toluene T=5°C; 2 h; 2: (2S-trans)-L-glutamine With sodium hydroxide in water; toluene; Petroleum ether T=10°C; pH=12; 1.5 h; 3: With hydrogenchloride; sulfuric acid Product distribution / selectivity; more than 3 stages;
1: N-(O,O-dimethyl) phosphoalanine With 1,2,2-trichloro-1,1,2-trichloro-ethane; triphenylphosphine in tetrahydrofuran T=10°C; 0.333333 h; 2: (2S-trans)-L-glutamine With sodium hydroxide in tetrahydrofuran; cyclohexane; water T=25°C; pH=12; 0.5 h; 3: With hydrogen bromide; nitric acid Product distribution / selectivity; more than 3 stages;
1: With sodium carbonate in water 1 h; Inert atmosphere; 2: With hydrogenchloride in water 1 h;
参考文献
Muller, George W.; Konnecke, William E.; Smith, Alison M.; Khetani, Vikram D.
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 139 - 140
