2-氨基-4-氯-6-甲基嘧啶合成路线 （共 44 条）
反应条件
1: With ammonia in methanol T=160°C; 15 h; 2: With iodine cloride in methanol T=25°C; 14.8333 h; 3: With sodium hydroxide in water T=25°C; 2 h;
参考文献
University of Connecticut
Patent: US2009/105287 A1, 2009 ;
Location in patent: Page/Page column 27 ;
US 20090105287 A1
反应条件
in methanol 18 h; Heating;
参考文献
Sacchi; Laneri; Arena; Luraschi; Abignente; D'Amico; Berrino; Rossi
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 7-8 p. 677 - 682
反应条件
in methanol 18 h; Heating;
参考文献
Sacchi; Laneri; Arena; Luraschi; Abignente; D'Amico; Berrino; Rossi
European Journal of Medicinal Chemistry, 1997 , vol. 32, # 7-8 p. 677 - 682
反应条件
potassium hydroxide in water T=165°C; 0.0833333 h; Microwave;
参考文献
PHARMAGENE LABORATORIES LIMITED
Patent: WO2005/12263 A1, 2005 ;
Location in patent: Page/Page column 79-80 ;
WO 2005/012263 A1
反应条件
1: alcoholic ammonia / 160 °C 2: HNO3+H2SO4 / 70 °C View Scheme
参考文献
Gabriel; Colman
Chemische Berichte, 1901 , vol. 34, p. 1242
反应条件
N-iodo-succinimide in water T=20°C;
参考文献
Lin, Songwen; Han, Fangbin; Liu, Peng; Tao, Jing; Zhong, Xuechao; Liu, Xiujie; Yi, Chongqin; Xu, Heng
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 790 - 793
反应条件
1: methanol 2: aqueous NaNO2; aqueous HCl View Scheme
参考文献
Sirakawa et al.
Yakugaku Zasshi, 1953 , vol. 73, p. 598,600
Chem.Abstr., 1954 , p. 9362
参考文献
Sirakawa et al.
Yakugaku Zasshi, 1953 , vol. 73, p. 598,600
Chem.Abstr., 1954 , p. 9362
Full Text Show Details
Backer; Grevenstuk
Recueil des Travaux Chimiques des Pays-Bas, 1942 , vol. 61, p. 291,297
Full Text Show Details
Braker et al.
Journal of the American Chemical Society, 1947 , vol. 69, p. 3072,3075
反应条件
in methanol 3.5 h; Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 29, # 4 p. 279 - 286
参考文献
European Journal of Medicinal Chemistry, , vol. 29, # 4 p. 279 - 286
