2-氨基-4-氯-6-甲基嘧啶合成路线 （共 44 条）
反应条件
C70H40Cl2F68N2O6Pd2; tetrabutylammomium bromide; potassium carbonate in water T=140°C; Suzuki-Miyaura reaction; 0.633333 h; Microwave irradiation;
参考文献
Susanto, Woen; Chu, Chi-Yuan; Ang, Wei Jie; Chou, Tzyy-Chao; Lo, Lee-Chiang; Lam, Yulin
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2729 - 2742
反应条件
1: bromine / dichloromethane / 20 °C 2: toluene-4-sulfonic acid / toluene / 24 h / Reflux View Scheme
参考文献
Astar Biotech LLC; Yu, Chunrong; Huang, Yong
Patent: US2014/38991 A1, 2014 ;
参考文献
Tsuda; Ogawa
Yakugaku Zasshi, 1948 , vol. 68, p. 103
Chem.Abstr., 1953 , p. 7453
反应条件
T=60 - 65°C; Elektrolytische Reduktion vom pH 7.9;
参考文献
Sugino et al.
J.electroch.Soc., 1957 , vol. 104, p. 667,670
参考文献
Gabriel; Colman
Chemische Berichte, 1899 , vol. 32, p. 2934
Chemische Berichte, 1902 , vol. 35, p. 1570
反应条件
bromine in dichloromethane T=20°C; 1.5 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/32162 A1, 2008 ;
Location in patent: Page/Page column 62-63 ;
反应条件
potassium carbonate in acetonitrile Heating;
参考文献
Ge, Hai-Xia; Wang, Li-Chen; Jiang, Zhen-Zhou; Ni, Sheng-Liang
Arzneimittel-Forschung/Drug Research, 2006 , vol. 56, # 10 p. 673 - 677
参考文献
Sirakawa et al.
Yakugaku Zasshi, 1953 , vol. 73, p. 598,600
Chem.Abstr., 1954 , p. 9362
Full Text Show Details
Claesen; Vanderhaeghe
Bulletin des Societes Chimiques Belges, 1959 , vol. 68, p. 30,55
Full Text Show Details
Shiho; Takahayashi
Yakugaku Zasshi, 1955 , vol. 75, p. 773
Chem.Abstr., 1956 , p. 4976
参考文献
FMC Corporation
Patent: US5521192 A1, 1996 ;
反应条件
potassium hydroxide in water
参考文献
Shaw University
Patent: US4083841 A1, 1978 ;
