2-氨基-5-硝基-苯甲醛合成路线 （共 18 条）
反应条件
hydrogenchloride; acetic acid 10 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 18 p. 2689 - 2700
反应条件
1: 86 percent / conc. HCl, glacial AcOH / 10 h / Heating 2: 50 percent / SnCl2, conc. HCl / 2 h / Ambient temperature View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
参考文献
Cohn; Springer
Monatshefte fuer Chemie, 1903 , vol. 24, p. 91
参考文献
Cohn; Springer
Monatshefte fuer Chemie, 1903 , vol. 24, p. 91
反应条件
1: 48 percent / 1.67 h / 120 - 160 °C 2: 32 percent / H2 / 10percent Pd/C / ethanol / 0.5 h / Ambient temperature View Scheme
参考文献
Wall, Monroe E.; Wani, Mansukh C.; Nicholas, Allan W.; Manikumar, Govindarajan; Tele, Chhagan; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2689 - 2700
反应条件
T=120 - 160°C; 1.66667 h;
参考文献
Wani; Nicholas; Wall
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2358 - 2363
反应条件
manganese(IV) oxide in dichloromethane
T=20°C; 23 h; Inert atmosphere;
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
反应条件
sulfuric acid
Deacetylation; 1 h; Heating;
参考文献
Dave, Rajesh H.; Hosangadi, Bhaskar D.
Tetrahedron, 1999 , vol. 55, # 37 p. 11295 - 11308
反应条件
1: With trichlorophosphate
T=0 - 80°C; Vilsmeier-Haack reaction;
2: With sodium hydroxide in N,N-dimethyl-formamide
Further stages.;
参考文献
Kiran; Mahadevan
Heterocyclic Communications, 2006 , vol. 12, # 6 p. 481 - 484
反应条件
1: borane-THF / tetrahydrofuran / 23 h / 0 - 30 °C / |Inert atmosphere
2: manganese(IV) oxide / dichloromethane / 23 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
