1.1: oxalyl chloride; DMF / CH2Cl2 / 12 h / 20 °C 2.1: Et3N / CH2Cl2 / 4 h / 0 - 20 °C 2.2: 93 percent / AcONa / acetic acid / 15 h / Heating 3.1: NaH / tetrahydrofuran / 0 - 20 °C 3.2: 92 percent / tetrahydrofuran / 13 h / 20 °C 4.1: 93 percent / NaOH / methanol / 0.42 h / Heating 5.1: H2 / Pd/C / methanol / 24 h / atmospheric pressure View Scheme

1.1: Et3N / CH2Cl2 / 4 h / 0 - 20 °C 1.2: 93 percent / AcONa / acetic acid / 15 h / Heating 2.1: NaH / tetrahydrofuran / 0 - 20 °C 2.2: 92 percent / tetrahydrofuran / 13 h / 20 °C 3.1: 93 percent / NaOH / methanol / 0.42 h / Heating 4.1: H2 / Pd/C / methanol / 24 h / atmospheric pressure View Scheme

1.1: NaH / tetrahydrofuran / 0 - 20 °C 1.2: 92 percent / tetrahydrofuran / 13 h / 20 °C 2.1: 93 percent / NaOH / methanol / 0.42 h / Heating 3.1: H2 / Pd/C / methanol / 24 h / atmospheric pressure View Scheme