1: 2-(hydroxyethyl)benzolt;bgt;thiophene With sodium hydride in tetrahydrofuran T=0°C; 0.75 h; 2: chloromethyl methyl ether in tetrahydrofuran T=20°C; 72 h;

1.1: BuLi; N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran; hexane / 1.75 h / -25 °C 1.2: 84 percent / tetrahydrofuran; hexane / 4 h / -25 - 20 °C 2.1: NaH / tetrahydrofuran / 0.75 h / 0 °C 2.2: 90 percent / tetrahydrofuran / 72 h / 20 °C View Scheme

Multistep reaction. Title compound not separated from byproducts;